The kiss/kissr Systems Are Dispensable for Zebrafish Reproduction: Evidence From Gene Knockout Studies

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	The kiss/kissr Systems Are Dispensable for Zebrafish Reproduction: Evidence From Gene Knockout Studies
	Tang, Haipei 1,2; Liu, Yun 1,3,6; Luo, Daji 4,5; Ogawa, Satoshi 7; Yin, Yike 2; Li, Shuisheng 1,2; Zhang, Yong 1,2,3; Hu, Wei 4; Parhar, Ishwar S.7; Lin, Haoran 1,2
刊名	ENDOCRINOLOGY
	2015-02-01
卷号	156 期号:2 页码:589-599
ISSN号	0013-7227
通讯作者	Cheng, CHK (reprint author), Chinese Univ Hong Kong, Room 604A,6-F, Shatin, Hong Kong, Peoples R China.
英文摘要	The kiss1/gpr54 signaling system is considered to be a critical regulator of reproduction in most vertebrates. However, this presumption has not been tested vigorously in nonmammalian vertebrates. Distinct from mammals, multiple kiss1/gpr54 paralogous genes (kiss/kissr) have been identified in nonmammalian vertebrates, raising the possibility of functional redundancy among these genes. In this study, we have systematically generated the zebrafish kiss1(-/-), kiss2(-/-), and kiss1(-/-); kiss2-/- mutant lines as well as the kissr1(-/-), kissr2(-/-), and kissr1(-/-); kissr2(-/-) mutant lines using transcription activator-like effector nucleases. We have demonstrated that spermatogenesis and folliculogenesis as well as reproductive capability are not impaired in all of these 6 mutant lines. Collectively, our results indicate that kiss/kissr signaling is not absolutely required for zebrafish reproduction, suggesting that the kiss/kissr systems play nonessential roles for reproduction in certain nonmammalian vertebrates. These findings also demonstrated that fish and mammals have evolved different strategies for neuroendocrine control of reproduction.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Endocrinology & Metabolism
研究领域[WOS]	Endocrinology & Metabolism
关键词[WOS]	GOLDFISH CARASSIUS-AURATUS ; KISSPEPTIN/KISSPEPTIN RECEPTOR SYSTEM ; MACKEREL SCOMBER-JAPONICUS ; GONADAL DEVELOPMENT ; NEUROENDOCRINE REGULATION ; GONADOTROPIN-SECRETION ; EVOLUTIONARY INSIGHTS ; TELEOST FISH ; KISSPEPTIN ; GPR54
收录类别	SCI
语种	英语
WOS记录号	WOS:000353131800019
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/23896]
专题	水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文
作者单位	1.Sun Yat Sen Univ, Sch Life Sci, Inst Aquat Econ Anim, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China 2.Sun Yat Sen Univ, Sch Life Sci, Guangdong Prov Key Lab Aquat Econ Anim, Guangzhou 510275, Guangdong, Peoples R China 3.Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China 4.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430070, Peoples R China 5.Wuhan Univ, Sch Basic Med Sci, Dept Genet, Wuhan 430072, Peoples R China 6.Chinese Univ Hong Kong, Shenzhen Res Inst, Sch Biomed Sci, Core Lab, Shenzhen 518057, Peoples R China 7.Monash Univ Malaysia, Sch Med & Hlth Sci, Brain Res Inst, Bandar Sunway 47500, Malaysia
推荐引用方式 GB/T 7714	Tang, Haipei,Liu, Yun,Luo, Daji,et al. The kiss/kissr Systems Are Dispensable for Zebrafish Reproduction: Evidence From Gene Knockout Studies[J]. ENDOCRINOLOGY,2015,156(2):589-599.
APA	Tang, Haipei.,Liu, Yun.,Luo, Daji.,Ogawa, Satoshi.,Yin, Yike.,...&Cheng, Christopher H. K..(2015).The kiss/kissr Systems Are Dispensable for Zebrafish Reproduction: Evidence From Gene Knockout Studies.ENDOCRINOLOGY,156(2),589-599.
MLA	Tang, Haipei,et al."The kiss/kissr Systems Are Dispensable for Zebrafish Reproduction: Evidence From Gene Knockout Studies".ENDOCRINOLOGY 156.2(2015):589-599.