FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity

CORC > 水生生物研究所 > 中科院水生所知识产出（2009年前） > 水生生物分子与细胞生物学研究中心 > 期刊论文

	FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity
	Mei, Zhichao 1; Zhang, Dawei 1; Hu, Bo 1; Wang, Jing 1; Shen, Xian 3; Xiao, Wuhan 1,2
刊名	JOURNAL OF BIOLOGICAL CHEMISTRY
	2015-06-26
卷号	290 期号:26 页码:16202-16214
关键词	cell proliferation muscle atrophy Myc (c-Myc) oncogene ubiquitylation (ubiquitination) FBXO32 proteasomal degradation
ISSN号	0021-9258
通讯作者	Xiao, WH (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.
英文摘要	Background: FBXO32 is an E3 ubiquitin ligase that plays important roles in tumorigenesis and muscle atrophy. Results: c-Myc was found to be a target of FBXO32 for proteasomal degradation. Conclusion: FBXO32 targets Lys-326 of c-Myc to form polyubiquitin chains, resulting in inhibition of cell proliferation. Significance: FBXO32 may mediate c-Myc proteasomal degradation.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemistry & Molecular Biology
研究领域[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	SKELETAL-MUSCLE ATROPHY ; FOXO TRANSCRIPTION FACTORS ; UBIQUITIN LIGASE ; DEPENDENT DEGRADATION ; PROTEIN EXPRESSION ; TUMOR-SUPPRESSOR ; GENE-EXPRESSION ; MESSENGER-RNA ; PHOSPHORYLATION ; IDENTIFICATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000356930100024
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/23968]
专题	水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文
作者单位	1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 3.Wenzhou Med Univ, Hosp 1, Wenzhou 325000, Peoples R China
推荐引用方式 GB/T 7714	Mei, Zhichao,Zhang, Dawei,Hu, Bo,et al. FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2015,290(26):16202-16214.
APA	Mei, Zhichao,Zhang, Dawei,Hu, Bo,Wang, Jing,Shen, Xian,&Xiao, Wuhan.(2015).FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity.JOURNAL OF BIOLOGICAL CHEMISTRY,290(26),16202-16214.
MLA	Mei, Zhichao,et al."FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity".JOURNAL OF BIOLOGICAL CHEMISTRY 290.26(2015):16202-16214.