Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae

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	Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae
	Zhu, Biran 1,2; Wang, Qiangwei 1,2; Wang, Xianfeng 1,2; Zhou, Bingsheng 1
刊名	AQUATIC TOXICOLOGY
	2014-12-01
卷号	157 页码:186-195
关键词	Pb BDE-209 Co-exposure Thyroid disruption Thyroid hormones Synergistic effects
ISSN号	0166-445X
通讯作者	Zhou, BS (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.
英文摘要	Polybrominated diphenyl ethers (PBDEs) and metals are the main contaminants at waste electrical and electronic equipment ("e-waste") recycling sites. However, the potential environmental health effects of mixtures of PBDEs and metals are not known. We investigated co-exposure of lead (Pb) with decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae. Seven groups of embryos/larvae of zebrafish were treated with Pb (0, 2, 5, 10, 15, 20, and 30 mu g/L), six groups were exposed to BDE-209 (0, 50, 100, 200, 400, and 800 mu g/L), and nine groups of zebrafish larvae were treated with Pb and BDE-209 (5, 10, and 20 mu g/L Pb; 50, 100, and 200 mu g/L BDE-209). Embryos/larvae were exposed from 2 h post-fertilization (hpf) until 144 hpf, and thyroid hormone (TH) content measured. Pb exposure significantly decreased whole-body TH contents (triiodothyroxine (T-3) and thyroxine (T-4)) but BDE-209 exposure significantly increased T-3 and T-4 levels. Pb or BDE-209 treatment alone caused a predicted downregulation of TH transport (i.e., expression of the mRNA or proteins of transthyretin). Chemical analyses showed Pb uptake to be increased by BDE-209, but BDE-209 bioconcentration was decreased and the ability to metabolize BDE-209 was reduced in the presence of Pb. We also found that a mixture of the two chemicals had a synergistic effect on TH levels in zebrafish. (C) 2014 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Marine & Freshwater Biology ; Toxicology
研究领域[WOS]	Marine & Freshwater Biology ; Toxicology
关键词[WOS]	POLYBROMINATED DIPHENYL ETHERS ; PEARL RIVER DELTA ; BROMINATED FLAME RETARDANTS ; TROUT ONCORHYNCHUS-MYKISS ; WASTE DISMANTLING REGION ; ELECTRONIC-WASTE ; SOUTH CHINA ; ENDOCRINE DISRUPTION ; POLYCHLORINATED-BIPHENYLS ; DEVELOPMENTAL EXPOSURE
收录类别	SCI
语种	英语
WOS记录号	WOS:000346547800020
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/23959]
专题	水生生物研究所_水环境工程研究中心_期刊论文
作者单位	1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Biran,Wang, Qiangwei,Wang, Xianfeng,et al. Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae[J]. AQUATIC TOXICOLOGY,2014,157:186-195.
APA	Zhu, Biran,Wang, Qiangwei,Wang, Xianfeng,&Zhou, Bingsheng.(2014).Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae.AQUATIC TOXICOLOGY,157,186-195.
MLA	Zhu, Biran,et al."Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae".AQUATIC TOXICOLOGY 157(2014):186-195.