A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula: A Trial on Shu-feng-jie-du Formula

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	A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula: A Trial on Shu-feng-jie-du Formula
	Song, Jianglong 1; Zhang, Fangbo 2; Tang, Shihuan 2; Liu, Xi 1; Gao, Yibo1 ; Lu, Peng1,2 ; Wang, Yanping 3; Yang, Hongjun 2
刊名	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
	2013
英文摘要	At the molecular level, it is acknowledged that a TCM formula is often a complex system, which challenges researchers to fully understand its underlying pharmacological action. However, module detection technique developed from complex network provides new insight into systematic investigation of the mode of action of a TCM formula from the molecule perspective. We here proposed a computational approach integrating the module detection technique into a 2-class heterogeneous network (2-HN) which models the complex pharmacological system of a TCM formula. This approach takes three steps: construction of a 2-HN, identification of primary pharmacological units, and pathway analysis. We employed this approach to study Shu-feng-jie-du (SHU) formula, which aimed at discovering its molecular mechanism in defending against influenza infection. Actually, four primary pharmacological units were identified from the 2-HN for SHU formula and further analysis revealed numbers of biological pathways modulated by the four pharmacological units. 24 out of 40 enriched pathways that were ranked in top 10 corresponding to each of the four pharmacological units were found to be involved in the process of influenza infection. Therefore, this approach is capable of uncovering the mode of action underlying a TCM formula via module analysis.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Integrative & Complementary Medicine
研究领域[WOS]	Integrative & Complementary Medicine
关键词[WOS]	INFLUENZA-VIRUS INFECTION ; CELL-CYCLE ARREST ; EPITHELIAL-CELLS ; COMMUNITY STRUCTURE ; INDEPENDENT MECHANISMS ; INTERACTION NETWORKS ; BIOLOGICAL NETWORKS ; DRUG DISCOVERY ; TARGET NETWORK ; PROTEIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000328024100001
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/4155]
专题	自动化研究所_综合信息系统研究中心
作者单位	1.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 2.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China 3.China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China
推荐引用方式 GB/T 7714	Song, Jianglong,Zhang, Fangbo,Tang, Shihuan,et al. A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula: A Trial on Shu-feng-jie-du Formula[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA	Song, Jianglong.,Zhang, Fangbo.,Tang, Shihuan.,Liu, Xi.,Gao, Yibo.,...&Yang, Hongjun.(2013).A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula: A Trial on Shu-feng-jie-du Formula.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA	Song, Jianglong,et al."A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula: A Trial on Shu-feng-jie-du Formula".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).