Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer
	Ke, Hengte 1,2,3; Yue, Xiuli 3; Wang, Jinrui 1,2; Xing, Sen 3; Zhang, Qian4 ; Dai, Zhifei 1,2; Tian, Jie5 ; Wang, Shumin 1,2; Jin, Yushen3
刊名	SMALL
	2014-03-01
卷号	10 期号:6 页码:1220-1227
关键词	gold nanoshell liquid perfluorocarbon ultrasound imaging CT imaging photothermal therapy
英文摘要	The integration of multimodal contrast-enhanced diagnostic imaging and therapeutic capabilities could utilize imaging guided therapy to plan the treatment strategy based on the diagnostic results and to guide/monitor the therapeutic procedures. Herein, gold nanoshelled perfluorooctylbromide (PFOB) nanocapsules with PEGylation (PGsP NCs) are constructed by oil-in-water emulsion method to form polymeric PFOB nanocapsules, followed by the formation of PEGylated gold nanoshell on the surface. PGsP NCs could not only provide excellent contrast enhancement for dual modal ultrasound and CT imaging in vitro and in vivo, but also serve as efficient photoabsorbers for photothermal ablation of tumors on xenografted nude mouse model. To our best knowledge, this is the first report of gold nanoshell serving as both CT contrast agents and photoabsorbers for photothermal therapy. The novel multifunctional nanomedicine would be of great value to offer more comprehensive diagnostic information to guide more accurate and effective cancer therapy.
WOS标题词	Science & Technology ; Physical Sciences ; Technology
类目[WOS]	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]	RAY COMPUTED-TOMOGRAPHY ; CONTRAST AGENTS ; MACROPHAGE ENDOCYTOSIS ; OPTICAL-PROPERTIES ; NANOPARTICLES ; HYPERTHERMIA ; RADIATION ; NANOCAGES ; NANORODS ; TUMORS
收录类别	SCI
语种	英语
WOS记录号	WOS:000333538000024
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/4111]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China 2.Peking Univ, Hosp 3, Beijing 100871, Peoples R China 3.Harbin Inst Technol, State Key Lab Urban Water Resources & Environm, Sch Life Sci & Technol, Harbin 150080, Peoples R China 4.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China 5.Chinese Acad Sci, Intelligent Med Ctr, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Ke, Hengte,Yue, Xiuli,Wang, Jinrui,et al. Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer[J]. SMALL,2014,10(6):1220-1227.
APA	Ke, Hengte.,Yue, Xiuli.,Wang, Jinrui.,Xing, Sen.,Zhang, Qian.,...&Jin, Yushen.(2014).Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer.SMALL,10(6),1220-1227.
MLA	Ke, Hengte,et al."Gold Nanoshelled Liquid Perfl uorocarbon Nanocapsules for Combined Dual Modal Ultrasound/CT Imaging and Photothermal Therapy of Cancer".SMALL 10.6(2014):1220-1227.