Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models
	Liu, Kai 1; Lu, Yujie 2; Tian, Jie1,3 ; Qin, Chenghu 1; Yang, Xin1 ; Zhu, Shouping 3; Yang, Xiang1,3 ; Gao, Quansheng 4; Han, Dong 1
刊名	OPTICS EXPRESS
	2010-09-27
卷号	18 期号:20 页码:20988-21002
英文摘要	In vivo bioluminescence imaging (BLI) has played a more and more important role in biomedical research of small animals. Bioluminescence tomography (BLT) further translates the BLI optical information into three-dimensional bioluminescent source distribution, which could greatly facilitate applications in related studies. Although the diffusion approximation (DA) is one of the most widely-used forward models, higher-order approximations are still needed for in vivo small animal imaging. In this work, as a higher-order approximation theory, the performance of the simplified spherical harmonics approximation (SPN) in BLT is evaluated thoroughly on heterogeneous mouse models. In the numerical validations, the SPN based results demonstrate better imaging quality compared with diffusion approximation heterogeneously under various source locations over wide optical domain. In what follows, heterogeneous experimental BLT reconstructions using in vivo mouse further evaluate the capability of the higher-order method for practical biomedical applications. (C) 2010 Optical Society of America
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Optics
研究领域[WOS]	Optics
关键词[WOS]	DIFFUSE OPTICAL TOMOGRAPHY ; IMAGE-RECONSTRUCTION ; BIOLOGICAL TISSUE ; RADIATIVE-TRANSFER ; PHOTON MIGRATION ; LIGHT TRANSPORT ; SIMULATION ; EQUATIONS ; FEASIBILITY ; SYSTEM
收录类别	SCI
语种	英语
WOS记录号	WOS:000283679200045
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/3933]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing 100190, Peoples R China 2.Univ Calif Los Angeles, David Geffen Sch Med, Crump Inst Mol Imaging, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA 3.Xidian Univ, Sch Life Sci & Technol, Life Sci Ctr, Xian 710071, Shaanxi, Peoples R China 4.Acad Mil Med Sci, Lab Anim Ctr, Beijing 100850, Peoples R China
推荐引用方式 GB/T 7714	Liu, Kai,Lu, Yujie,Tian, Jie,et al. Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models[J]. OPTICS EXPRESS,2010,18(20):20988-21002.
APA	Liu, Kai.,Lu, Yujie.,Tian, Jie.,Qin, Chenghu.,Yang, Xin.,...&Han, Dong.(2010).Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models.OPTICS EXPRESS,18(20),20988-21002.
MLA	Liu, Kai,et al."Evaluation of the simplified spherical harmonics approximation in bioluminescence tomography through heterogeneous mouse models".OPTICS EXPRESS 18.20(2010):20988-21002.