Distinct resting-state brain activities in heroin-dependent individuals

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Distinct resting-state brain activities in heroin-dependent individuals
	Zhang, Yi 1,2; Tian, Jie1,3 ; Yuan, Kai 1; Liu, Peng 1; Zhuo, Lu 1; Qin, Wei 1; Zhao, Liyan 4; Liu, Jixin 1; von Deneen, Karen M.1,2; Klahr, Nelson J.2
刊名	BRAIN RESEARCH
	2011-07-21
卷号	1402 页码:46-53
关键词	Heroin-dependent individuals Pattern classification Multi-voxel pattern analysis (MVPA) Non-negative matrix factorization (NMF) Support vector machine (SVM)
英文摘要	Previous functional imaging studies on heroin addicts have focused on abnormal brain functions based on specific tasks, while few fMRI studies concentrated on the resting-state abnormalities of heroin-dependent individuals. In the current study, we applied the pattern classification technique, which employs the feature extraction method of non-negative matrix factorization (NMF) and a support vector machine (SVM) classifier. Its main purpose was to characterize the discrepancy in activation patterns between heroin-dependent individuals and healthy subjects during the resting state. The results displayed a high accuracy in the activation pattern differences of the two groups, which included the orbitofrontal cortex pm, cingulate gyrus, frontal and para-limbic regions such as the anterior cingulate cortex (ACC), hippocampal/parahippocampal region, amygdala, caudate, putamen, as well as the posterior insula and thalamus. These findings indicate that significant biomarkers exist among the network of circuits that are involved in drug abuse. The implications from our study may help explain the behavioral and neuropsychological deficits in heroin-dependent individuals and shed light on the mechanisms underlying heroin addiction. (C) 2011 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	STRIATAL DOPAMINE RELEASE ; SUPPORT VECTOR MACHINES ; HUMAN VISUAL-CORTEX ; COCAINE ADDICTION ; ORBITOFRONTAL CORTEX ; NEUROIMAGING EVIDENCE ; SUBJECTIVE RESPONSES ; DRUG-ADDICTION ; FMRI DATA ; STRESS
收录类别	SCI
语种	英语
WOS记录号	WOS:000293312300006
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/3925]
专题	自动化研究所_中国科学院分子影像重点实验室
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China 2.Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32610 USA 3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 4.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yi,Tian, Jie,Yuan, Kai,et al. Distinct resting-state brain activities in heroin-dependent individuals[J]. BRAIN RESEARCH,2011,1402:46-53.
APA	Zhang, Yi.,Tian, Jie.,Yuan, Kai.,Liu, Peng.,Zhuo, Lu.,...&Liu, Yijun.(2011).Distinct resting-state brain activities in heroin-dependent individuals.BRAIN RESEARCH,1402,46-53.
MLA	Zhang, Yi,et al."Distinct resting-state brain activities in heroin-dependent individuals".BRAIN RESEARCH 1402(2011):46-53.