Distinct resting-state brain activities in heroin-dependent individuals | |
Zhang, Yi1,2; Tian, Jie1,3![]() | |
刊名 | BRAIN RESEARCH
![]() |
2011-07-21 | |
卷号 | 1402页码:46-53 |
关键词 | Heroin-dependent individuals Pattern classification Multi-voxel pattern analysis (MVPA) Non-negative matrix factorization (NMF) Support vector machine (SVM) |
英文摘要 | Previous functional imaging studies on heroin addicts have focused on abnormal brain functions based on specific tasks, while few fMRI studies concentrated on the resting-state abnormalities of heroin-dependent individuals. In the current study, we applied the pattern classification technique, which employs the feature extraction method of non-negative matrix factorization (NMF) and a support vector machine (SVM) classifier. Its main purpose was to characterize the discrepancy in activation patterns between heroin-dependent individuals and healthy subjects during the resting state. The results displayed a high accuracy in the activation pattern differences of the two groups, which included the orbitofrontal cortex pm, cingulate gyrus, frontal and para-limbic regions such as the anterior cingulate cortex (ACC), hippocampal/parahippocampal region, amygdala, caudate, putamen, as well as the posterior insula and thalamus. These findings indicate that significant biomarkers exist among the network of circuits that are involved in drug abuse. The implications from our study may help explain the behavioral and neuropsychological deficits in heroin-dependent individuals and shed light on the mechanisms underlying heroin addiction. (C) 2011 Elsevier B.V. All rights reserved. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Neurosciences |
研究领域[WOS] | Neurosciences & Neurology |
关键词[WOS] | STRIATAL DOPAMINE RELEASE ; SUPPORT VECTOR MACHINES ; HUMAN VISUAL-CORTEX ; COCAINE ADDICTION ; ORBITOFRONTAL CORTEX ; NEUROIMAGING EVIDENCE ; SUBJECTIVE RESPONSES ; DRUG-ADDICTION ; FMRI DATA ; STRESS |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000293312300006 |
内容类型 | 期刊论文 |
源URL | [http://ir.ia.ac.cn/handle/173211/3925] ![]() |
专题 | 自动化研究所_中国科学院分子影像重点实验室 |
作者单位 | 1.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R China 2.Univ Florida, Dept Psychiat, McKnight Brain Inst, Gainesville, FL 32610 USA 3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 4.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Yi,Tian, Jie,Yuan, Kai,et al. Distinct resting-state brain activities in heroin-dependent individuals[J]. BRAIN RESEARCH,2011,1402:46-53. |
APA | Zhang, Yi.,Tian, Jie.,Yuan, Kai.,Liu, Peng.,Zhuo, Lu.,...&Liu, Yijun.(2011).Distinct resting-state brain activities in heroin-dependent individuals.BRAIN RESEARCH,1402,46-53. |
MLA | Zhang, Yi,et al."Distinct resting-state brain activities in heroin-dependent individuals".BRAIN RESEARCH 1402(2011):46-53. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论