Improvement of white matter and functional connectivity abnormalities by repetitive transcranial magnetic stimulation in crossed aphasia in dextral

	Improvement of white matter and functional connectivity abnormalities by repetitive transcranial magnetic stimulation in crossed aphasia in dextral
	Lu, Haitao 1; Wu, Haiyan 2; Cheng, Hewei 3; Wei, Dongjie 3; Wang, Xiaoyan 1; Fan, Yong 3; Zhang, Hao 1; Zhang, Tong 1
刊名	INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
	2014
卷号	7 期号:10 页码:3659-3668
关键词	Crossed aphasia in dextral diffusion tensor imaging functional magnetic resonance imaging positron emission tomography repetitive transcranial magnetic stimulation
英文摘要	As a special aphasia, the occurrence of crossed aphasia in dextral (CAD) is unusual. This study aims to improve the language ability by applying 1 Hz repetitive transcranial magnetic stimulation (rTMS). We studied multiple modality imaging of structural connectivity (diffusion tensor imaging), functional connectivity (resting fMRI), PET, and neurolinguistic analysis on a patient with CAD. Furthermore, we applied rTMS of 1 Hz for 40 times and observed the language function improvement. The results indicated that a significantly reduced structural and function connectivity was found in DTI and fMRI data compared with the control. The PET imaging showed hypo-metabolism in right hemisphere and left cerebellum. In conclusion, one of the mechanisms of CAD is that right hemisphere is the language dominance. Stimulating left Wernicke area could improve auditory comprehension, stimulating left Broca's area could enhance expression, and the results outlasted 6 months by 1 Hz rTMS balancing the excitability inter-hemisphere in CAD.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Medicine, Research & Experimental
研究领域[WOS]	Research & Experimental Medicine
关键词[WOS]	LOW-FREQUENCY RTMS ; CORTICAL ORGANIZATION ; POSTSTROKE APHASIA ; ARCUATE FASCICULUS ; BROCAS AREA ; LANGUAGE ; BRAIN ; SPEECH ; PET ; PERFORMANCE
收录类别	SCI
语种	英语
WOS记录号	WOS:000345121100073
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/3206]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Capital Med Univ, Dept Neurorehabil, Sch Rehabil Med, China Rehabil Res Ctr, Beijing 100068, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Inst Automat, Ctr Brainnetome, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Lu, Haitao,Wu, Haiyan,Cheng, Hewei,et al. Improvement of white matter and functional connectivity abnormalities by repetitive transcranial magnetic stimulation in crossed aphasia in dextral[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2014,7(10):3659-3668.
APA	Lu, Haitao.,Wu, Haiyan.,Cheng, Hewei.,Wei, Dongjie.,Wang, Xiaoyan.,...&Zhang, Tong.(2014).Improvement of white matter and functional connectivity abnormalities by repetitive transcranial magnetic stimulation in crossed aphasia in dextral.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,7(10),3659-3668.
MLA	Lu, Haitao,et al."Improvement of white matter and functional connectivity abnormalities by repetitive transcranial magnetic stimulation in crossed aphasia in dextral".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 7.10(2014):3659-3668.