Neural mechanisms of oxytocin receptor gene mediating anxiety-related temperament

	Neural mechanisms of oxytocin receptor gene mediating anxiety-related temperament
	Wang, Junping 1; Qin, Wen 1; Liu, Bing2 ; Zhou, Yuan 3; Wang, Dawei 1; Zhang, Yunting 1; Jiang, Tianzi2 ; Yu, Chunshui 1,4
刊名	BRAIN STRUCTURE & FUNCTION
	2014-09-01
卷号	219 期号:5 页码:1543-1554
关键词	Amygdala Anxiety Imaging genetics Oxytocin receptor Single nucleotide polymorphism
英文摘要	A common variant (rs53576) of the OXTR gene has been implicated in a number of socio-emotional phenotypes, such as anxiety-related behavior. Previous studies have demonstrated that A-allele carriers have higher levels of physiological and dispositional stress reactivity and depressive symptomatology compared to those with the GG genotype, but the mediating neural mechanisms remain poorly understood. We combined voxel-based morphometry and resting-state functional connectivity analyses in a large cohort of healthy young Chinese Han individuals to test the hypothesis that the OXTR gene polymorphism influences an anxiety-related temperamental trait, as assessed by the harm avoidance subscale from the Tridimensional Personality Questionnaire via modulating the gray matter volume and resting-state functional connectivity of the brain, especially the limbic system. We revealed that female subjects with the AA genotype showed increased harm avoidance scores relative to G-carrier females. We also found that, compared to female individuals with the GG/GA genotype, female individuals with the AA genotype exhibited significantly smaller amygdala volumes bilaterally (especially the centromedial subregion), with a trend of allele-load-dependence. Compared to female individuals with the GG/GA genotype, female subjects with the AA genotype demonstrated reduced resting-state functional coupling between the prefrontal cortex and amygdala bilaterally, also with an allele-load-dependent trend. Furthermore, the magnitude of prefrontal-amygdala coupling in the left hemisphere was positively correlated with harm avoidance scores in female subjects. Our findings highlight a possible neural pathway by which a naturally occurring variation of the OXTR gene may affect an anxiety-related temperamental trait in female subjects by modulating prefrontal-amygdala functional connectivity.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Anatomy & Morphology ; Neurosciences
研究领域[WOS]	Anatomy & Morphology ; Neurosciences & Neurology
关键词[WOS]	MAJOR DEPRESSION ; HARM-AVOIDANCE ; INDIVIDUAL-DIFFERENCES ; PERSONALITY-TRAITS ; PREFRONTAL CORTEX ; SOCIAL COGNITION ; AMYGDALA ; OXTR ; HUMANS ; VASOPRESSIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000341375500003
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/3190]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 2.Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Ctr Social & Econ Behav, Beijing, Peoples R China 4.Tianjin Med Univ, Sch Med Imaging, Tianjin, Peoples R China
推荐引用方式 GB/T 7714	Wang, Junping,Qin, Wen,Liu, Bing,et al. Neural mechanisms of oxytocin receptor gene mediating anxiety-related temperament[J]. BRAIN STRUCTURE & FUNCTION,2014,219(5):1543-1554.
APA	Wang, Junping.,Qin, Wen.,Liu, Bing.,Zhou, Yuan.,Wang, Dawei.,...&Yu, Chunshui.(2014).Neural mechanisms of oxytocin receptor gene mediating anxiety-related temperament.BRAIN STRUCTURE & FUNCTION,219(5),1543-1554.
MLA	Wang, Junping,et al."Neural mechanisms of oxytocin receptor gene mediating anxiety-related temperament".BRAIN STRUCTURE & FUNCTION 219.5(2014):1543-1554.