Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI

	Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI
	Zang Yu-Feng ; He Yong ; Zhu Chao-Zhe ; Cao Qing-Jiu ; Sui Man-Qiu ; Liang Meng ; Tian Li-Xia ; Jiang Tian-Zi; Wang, Yu-Feng
刊名	BRAIN & DEVELOPMENT
	2007-03-01
卷号	29 期号:2 页码:83-91
关键词	attention deficit hyperactivity disorder resting-state functional MRI amplitude low-frequency fluctuation spontaneous neuronal activity
英文摘要	In children with attention deficit hyperactivity disorder (ADHD), functional neuroimaging studies have revealed abnormalities in various brain regions, including prefrontal-striatal circuit, cerebellum, and brainstem. In the current study, we used a new marker of functional magnetic resonance imaging (fMRI), amplitude of low-frequency (0.01-0.08 Hz) fluctuation (ALFF) to investigate the baseline brain function of this disorder. Thirteen boys with ADHD (13.0 +/- 1.4 years) were examined by resting-state fMRI and compared with age-matched controls. As a result, we found that patients with ADHD had decreased ALFF in the right inferior frontal cortex, left sensorimotor cortex, and bilateral cerebellum and the vermis as well as increased ALFF in the right anterior cingulated cortex, left sensorimotor cortex, and bilateral brainstem. This resting-state fMRI study suggests that the changed spontaneous neuronal activity of these regions may be implicated in the underlying pathophysiology in children with ADHD. (c) 2006 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Clinical Neurology
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	DEFICIT HYPERACTIVITY DISORDER ; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; CEREBRAL-BLOOD-FLOW ; EVENT-RELATED FMRI ; MAGNETIC-RESONANCE ; RESPONSE-INHIBITION ; DEFAULT-MODE ; METHYLPHENIDATE ; CONNECTIVITY ; BOYS
收录类别	SCI
语种	英语
WOS记录号	WOS:000244380400005
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/3189]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100871, Peoples R China 2.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Zang Yu-Feng,He Yong,Zhu Chao-Zhe,et al. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI[J]. BRAIN & DEVELOPMENT,2007,29(2):83-91.
APA	Zang Yu-Feng.,He Yong.,Zhu Chao-Zhe.,Cao Qing-Jiu.,Sui Man-Qiu.,...&Wang, Yu-Feng.(2007).Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI.BRAIN & DEVELOPMENT,29(2),83-91.
MLA	Zang Yu-Feng,et al."Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI".BRAIN & DEVELOPMENT 29.2(2007):83-91.