The Development of Visual Areas Depends Differently on Visual Experience

	The Development of Visual Areas Depends Differently on Visual Experience
	Qin, Wen 1; Liu, Yong2 ; Jiang, Tianzi2 ; Yu, Chunshui 1,3
刊名	PLOS ONE
	2013-01-07
卷号	8 期号:1
英文摘要	Visual experience plays an important role in the development of the visual cortex; however, recent functional imaging studies have shown that the functional organization is preserved in several higher-tier visual areas in congenitally blind subjects, indicating that maturation of visual areas depend unequally on visual experience. In this study, we aim to validate this hypothesis using a multimodality MRI approach. We found increased cortical thickness in the congenitally blind was present in the early visual areas and absent in the higher-tier ones, suggesting that the structural development of the visual cortex depends hierarchically on visual experience. In congenitally blind subjects, the decreased resting-state functional connectivity with the primary somatosensory cortex was more prominent in the early visual areas than in the higher-tier ones and were more pronounced in the ventral stream than in the dorsal one, suggesting that the development of functional organization of the visual cortex also depends differently on visual experience. Moreover, congenitally blind subjects showed normal or increased functional connectivity between ipsilateral higher-tier and early visual areas, suggesting an indirect corticocortical pathway through which somatosenroy information can reach the early visual areas. These findings support our hypothesis that the development of visual areas depends differently on visual experience.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	LATERAL OCCIPITAL COMPLEX ; EARLY BLIND SUBJECTS ; STATE FUNCTIONAL CONNECTIVITY ; CROSS-MODAL PLASTICITY ; SURFACE-BASED ANALYSIS ; HUMAN CEREBRAL-CORTEX ; MIDDLE TEMPORAL AREA ; CONGENITALLY BLIND ; AUDITORY SUBSTITUTION ; CORTICAL SURFACE
收录类别	SCI
语种	英语
WOS记录号	WOS:000313429100115
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/3177]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin, Peoples R China 2.Chinese Acad Sci, Natl Lab Pattern Recognit Inst Automat, LIAMA Ctr Computat Med, Beijing, Peoples R China 3.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Qin, Wen,Liu, Yong,Jiang, Tianzi,et al. The Development of Visual Areas Depends Differently on Visual Experience[J]. PLOS ONE,2013,8(1).
APA	Qin, Wen,Liu, Yong,Jiang, Tianzi,&Yu, Chunshui.(2013).The Development of Visual Areas Depends Differently on Visual Experience.PLOS ONE,8(1).
MLA	Qin, Wen,et al."The Development of Visual Areas Depends Differently on Visual Experience".PLOS ONE 8.1(2013).