Dosage Effects of BDNF Val66Met Polymorphism on Cortical Surface Area and Functional Connectivity

	Dosage Effects of BDNF Val66Met Polymorphism on Cortical Surface Area and Functional Connectivity
	Wang, Chao 1; Zhang, Yuanchao 1; Liu, Bing2,3 ; Long, Haixia 2,3; Yu, Chunshui 4; Jiang, Tianzi1,2,3,5
刊名	JOURNAL OF NEUROSCIENCE
	2014-02-12
卷号	34 期号:7 页码:2645-2651
关键词	anterior insula brain-derived neurotrophic factor (BDNF) functional connectivity surface area
英文摘要	The single nucleotide polymorphism (SNP) that leads to a valine-to-methionine substitution at codon 66 (Val66Met) in BDNF is correlated with differences in cognitive and memory functions, as well as with several neurological and psychiatric disorders. MRI studies have already shown that this genetic variant contributes to changes in cortical thickness and volume, but whether the Val66Met polymorphism affects the cortical surface area of healthy subjects remains unclear. Here, we used multimodal MRI to study whether this polymorphism would affect the cortical morphology and resting-state functional connectivity of a large sample of healthy Han Chinese human subjects. An SNP-wise general linear model analysis revealed a "dosage effect" of the Met allele, specifically a stepwise increase in cortical surface area of the right anterior insular cortex with increasing numbers of the Met allele. Moreover, we found enhanced functional connectivity between the anterior insular and the dorsolateral prefrontal cortices that was linked with the dosage of the Met allele. In conclusion, these data demonstrated a "dosage effect" of BDNF Val66Met on normal cortical structure and function, suggesting a new path for exploring the mechanisms underlying the effects of genotype on cognition.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	ACTIVITY-DEPENDENT SECRETION ; HUMAN CEREBRAL-CORTEX ; NEUROTROPHIC FACTOR ; VAL(66)MET POLYMORPHISM ; MAJOR DEPRESSION ; HIPPOCAMPAL FUNCTION ; PREFRONTAL CORTEX ; MENTAL-DISORDERS ; MESSENGER-RNA ; HUMAN-MEMORY
收录类别	SCI
语种	英语
WOS记录号	WOS:000331614700025
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/3150]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 4.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
推荐引用方式 GB/T 7714	Wang, Chao,Zhang, Yuanchao,Liu, Bing,et al. Dosage Effects of BDNF Val66Met Polymorphism on Cortical Surface Area and Functional Connectivity[J]. JOURNAL OF NEUROSCIENCE,2014,34(7):2645-2651.
APA	Wang, Chao,Zhang, Yuanchao,Liu, Bing,Long, Haixia,Yu, Chunshui,&Jiang, Tianzi.(2014).Dosage Effects of BDNF Val66Met Polymorphism on Cortical Surface Area and Functional Connectivity.JOURNAL OF NEUROSCIENCE,34(7),2645-2651.
MLA	Wang, Chao,et al."Dosage Effects of BDNF Val66Met Polymorphism on Cortical Surface Area and Functional Connectivity".JOURNAL OF NEUROSCIENCE 34.7(2014):2645-2651.