Neural mechanism of intertemporal choice: From discounting future gains to future losses

	Neural mechanism of intertemporal choice: From discounting future gains to future losses
	Xu, Lijuan 1; Liang, Zhu-Yuan 2; Wang, Kun 1; Li, Shu 2; Jiang, Tianzi1
刊名	BRAIN RESEARCH
	2009-03-19
卷号	1261 页码:65-74
关键词	Intertemporal choice Discounting loss Medial prefrontal cortex Anterior cingulate cortex Dorsolateral prefrontal cortex
英文摘要	Intertemporal choice, the tradeoff among outcomes occurring at different points in time, involves not only benefit options but also those associated with cost. Previous neuroimaging studies have primarily focused on discounting future gains; thus the neural mechanism underlying discounting future losses remains unidentified. Using event-related functional magnetic resonance imaging, we comprehensively investigated the neural mechanism of temporal discounting using two decision-making tasks with a symmetric pattern of gains and losses. Our results revealed that the lateral prefrontal and posterior parietal areas were activated in discounting both future gains and future losses, but their activations were stronger when discounting losses. Moreover, we found that the insula, thalamus and dorsal striatum were more activated during intertemporal choices involving losses, suggesting that the enhanced sensitivity to losses may be driven by negative emotions. In addition, whereas the posterior cingulate cortex and medial prefrontal cortex were activated when the choices included immediate options, extra regions including the anterior cingulate cortex, insula and superior frontal gyrus were preferentially activated when the choices involved immediate losses. Taken together, our findings suggest that a fronto-parietal network supports the common discounting process, and more importantly, discounting future losses and gains occurs asymmetrically in the brain. We speculate that this may provide a neural basis for the phenomenon that future losses are discounted less steeply than future gains. (C) 2008 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	ANTERIOR CINGULATE CORTEX ; DECISION-MAKING ; LOSS AVERSION ; HUMAN BRAIN ; PREFRONTAL CORTEX ; ORBITOFRONTAL CORTEX ; PREDICTION ERRORS ; TIME PREFERENCE ; MONETARY GAINS ; HUMAN STRIATUM
收录类别	SCI ; SSCI
语种	英语
WOS记录号	WOS:000264693300008
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/3127]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Chinese Acad Sci, Inst Automat, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Ctr Social & Econ Behav, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Xu, Lijuan,Liang, Zhu-Yuan,Wang, Kun,et al. Neural mechanism of intertemporal choice: From discounting future gains to future losses[J]. BRAIN RESEARCH,2009,1261:65-74.
APA	Xu, Lijuan,Liang, Zhu-Yuan,Wang, Kun,Li, Shu,&Jiang, Tianzi.(2009).Neural mechanism of intertemporal choice: From discounting future gains to future losses.BRAIN RESEARCH,1261,65-74.
MLA	Xu, Lijuan,et al."Neural mechanism of intertemporal choice: From discounting future gains to future losses".BRAIN RESEARCH 1261(2009):65-74.