Haplotypes of catechol-O-methyltransferase modulate intelligence-related brain white matter integrity

	Haplotypes of catechol-O-methyltransferase modulate intelligence-related brain white matter integrity
	Liu, Bing1 ; Li, Jun 2; Yu, Chunshui 3; Li, Yonghui 1; Liu, Yong1 ; Song, Ming1 ; Fan, Ming 1; Li, Kuncheng 3; Jiang, Tianzi1,4
刊名	NEUROIMAGE
	2010-03-01
卷号	50 期号:1 页码:243-249
关键词	COMT White matter integrity Haplotypes Diffusion tensor imaging Intelligence
英文摘要	Twin studies have indicated a common genetic origin for intelligence and for variations in brain morphology. Our previous diffusion tensor imaging studies found an association between intelligence and white matter integrity of specific brain regions or tracts. However, specific genetic determinants of the white matter integrity of these brain regions and tracts are still unclear. In this study, we assess whether and how catechol-O-methyltransferase (COMT) gene polymorphisms affect brain white matter integrity. We genotyped twelve single nucleotide polymorphisms (SNPs) within the COMT gene and performed haplotype analyses on data from 79 healthy subjects. Our subjects had the same three major COMT haplotypes (termed the HPS, APS and ILPS haplotypes) as previous studies have reported as regulating significantly different levels of enzymatic activity and dopamine. We used the mean fractional anisotropy (FA) values from four regions and five tracts of interest to assess the effect of COMT polymorphisms, including the well-studied val158met SNP and the three main haplotypes that we had identified, on intelligence-related white matter integrity. We identified an association between the mean FA values of two regions in the bilateral prefrontal lobes and the COMT haplotypes, rather than between them and val158met. The haplotype-FA value associations modulated nonlinearly and fit an inverted U-model. Our findings suggest that COMT haplotypes can nonlinearly modulate the intelligence-related white matter integrity of the prefrontal lobes by more significantly influencing prefrontal dopamine variations than does val158met. (C) 2009 Elsevier Inc. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]	DOPAMINE TRANSPORTER ; GENETIC INFLUENCES ; PREFRONTAL CORTEX ; HEALTHY-ADULTS ; GENERAL INTELLIGENCE ; COMT ; SCHIZOPHRENIA ; RAT ; POLYMORPHISM ; GENOTYPE
收录类别	SCI
语种	英语
WOS记录号	WOS:000274810100024
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/3118]
专题	自动化研究所_脑网络组研究中心
作者单位	1.Chinese Acad Sci, LIAMA Ctr Computat Med, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China 2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 3.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 4.Univ Elect Sci & Technol China, Key Lab Neuroinformat, Minist Educ, Sch Life Sci & Technol, Chengdu 610054, Peoples R China
推荐引用方式 GB/T 7714	Liu, Bing,Li, Jun,Yu, Chunshui,et al. Haplotypes of catechol-O-methyltransferase modulate intelligence-related brain white matter integrity[J]. NEUROIMAGE,2010,50(1):243-249.
APA	Liu, Bing.,Li, Jun.,Yu, Chunshui.,Li, Yonghui.,Liu, Yong.,...&Jiang, Tianzi.(2010).Haplotypes of catechol-O-methyltransferase modulate intelligence-related brain white matter integrity.NEUROIMAGE,50(1),243-249.
MLA	Liu, Bing,et al."Haplotypes of catechol-O-methyltransferase modulate intelligence-related brain white matter integrity".NEUROIMAGE 50.1(2010):243-249.