Assessment of 17 alpha-ethinylestradiol effects and underlying mechanisms in a continuous, multigeneration exposure of the Chinese rare minnow (Gobiocypris rarus)

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境水质学国家重点实验室

	Assessment of 17 alpha-ethinylestradiol effects and underlying mechanisms in a continuous, multigeneration exposure of the Chinese rare minnow (Gobiocypris rarus)
	Zha, Jinmiao; Sun, Liwei; Zhou, Yiqi; Spear, Philip A.; Ma, Mei; Wang, Zijian
刊名	TOXICOLOGY AND APPLIED PHARMACOLOGY
	2008-02-01
卷号	226 期号:3 页码:298-308
关键词	synthetic estrogen embryotoxicity reproductive toxicity malformations vitellogenin sexual ratio histopathology
英文摘要	17 alpha-Ethinylestradiol (EE2) is a synthetic estrogen used primarily in birth control pills and in hormone replacement therapy. Owing to its occurrence in surface waters at concentrations frequently greater than I ng/l and its projected future use, EE2 is expected to pose a significant risk to aquatic organisms. This study was conducted to obtain long-term exposure data necessary for the establishment of water quality criteria and to investigate mechanisms associated with toxic effects. In a multigeneration experiment, Chinese rare minnows (Gobiocypris rarus) were constantly exposed to environmentally relevant concentrations of the synthetic estrogen EE2. Mortality, deformities, reproductive parameters, plasma vitellogenin and histopathology were assessed. The results showed that, in the F-0 generation, all endpoints were significantly affected at concentrations higher than 0.2 ng/l EE2. No F-1 phenotypic males developed to maturity at 0.2 ng/l and, when adult females of this exposure group were crossed with unexposed males, no F-2 fertile eggs were produced. Kidney histopathology and ultrastructure suggest anomalies possibly associated with increased vitellogenin accumulation. We concluded that the reproduction of the F-1 minnows was completely inhibited at the lowest concentration tested, 0.2 ng/l EE2, a concentration frequently detected in surface waters. Growth effects may be related to increased energy requirements including the energy used in VTG synthesis. Reproductive effects are presumably associated with male feminization and the occurrence of testis-ova in males; however, ovarian degeneration observed in females may also have contributed to reproductive failure. (c) 2007 Elsevier Inc. All rights reserved.
WOS记录号	WOS:000253002200009
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/22211]
专题	生态环境研究中心_环境水质学国家重点实验室
推荐引用方式 GB/T 7714	Zha, Jinmiao,Sun, Liwei,Zhou, Yiqi,et al. Assessment of 17 alpha-ethinylestradiol effects and underlying mechanisms in a continuous, multigeneration exposure of the Chinese rare minnow (Gobiocypris rarus)[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2008,226(3):298-308.
APA	Zha, Jinmiao,Sun, Liwei,Zhou, Yiqi,Spear, Philip A.,Ma, Mei,&Wang, Zijian.(2008).Assessment of 17 alpha-ethinylestradiol effects and underlying mechanisms in a continuous, multigeneration exposure of the Chinese rare minnow (Gobiocypris rarus).TOXICOLOGY AND APPLIED PHARMACOLOGY,226(3),298-308.
MLA	Zha, Jinmiao,et al."Assessment of 17 alpha-ethinylestradiol effects and underlying mechanisms in a continuous, multigeneration exposure of the Chinese rare minnow (Gobiocypris rarus)".TOXICOLOGY AND APPLIED PHARMACOLOGY 226.3(2008):298-308.