On-line sample treatment LC system for MS compatibility

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	On-line sample treatment LC system for MS compatibility
	Hashi, Yuki ; Yao, Jian-Guo ; Li, Yue-Qi ; Liu, Yan ; Lin, Jin-Ming
刊名	CHROMATOGRAPHIA
	2008-05
卷号	67 期号:1 页码:773-776
关键词	column liquid chromatography-mass spectrometry on-line sample pretreatment natural products coptidis Rhizoma
英文摘要	In the present work, a new liquid chromatography-mass spectrometry (LC-MS) system with on-line pretreatment using column switching and a dilution function was developed. This system can be used under conventional high-performance liquid chromatography (LC) separation conditions, including mobile phases containing phosphate buffer. The built-in autodilution function greatly improves the trapping efficiency for target compounds, followed by desaltation that optimizes the ionization conditions for MS analysis. This fully automated two-dimensional LC system interfaced with mass spectrometry provided a powerful tool for the determination of impurity profiles in pharmaceutical research and the identification of traditional Chinese medicine in natural products.
WOS记录号	WOS:000255751100016
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/21967]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Hashi, Yuki,Yao, Jian-Guo,Li, Yue-Qi,et al. On-line sample treatment LC system for MS compatibility[J]. CHROMATOGRAPHIA,2008,67(1):773-776.
APA	Hashi, Yuki,Yao, Jian-Guo,Li, Yue-Qi,Liu, Yan,&Lin, Jin-Ming.(2008).On-line sample treatment LC system for MS compatibility.CHROMATOGRAPHIA,67(1),773-776.
MLA	Hashi, Yuki,et al."On-line sample treatment LC system for MS compatibility".CHROMATOGRAPHIA 67.1(2008):773-776.