Simultaneous determination of 15 steroidal oral contraceptives in water using solid-phase disk extraction followed by high performance liquid chromatography-tandem mass spectrometry

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Simultaneous determination of 15 steroidal oral contraceptives in water using solid-phase disk extraction followed by high performance liquid chromatography-tandem mass spectrometry
	Sun, Li; Yong, Wei; Chu, Xiaogan; Lin, Jin-Ming
刊名	JOURNAL OF CHROMATOGRAPHY A
	2009-07-10
卷号	1216 期号:28 页码:5416-5423
关键词	Steroidal hormone Water analysis UPLC-MS/MS Solid-phase disk extraction
中文摘要	A rapid, accurate and sensitive method for simultaneous determination of 15 steroidal hormones including four estrogens (estrone, 17 beta-estradiol, 17 alpha-ethynylestradiol, estriol) and eleven progestogens (17 beta-estradiol-3-benzoate, 19-norethindrone, gestodene. levonorgestrel, medroxyprogesterone, cyproterone acetate, megestrol-17-acetate, progesterone, norethindrone acetate, chlormadinone-17-acetate, and hydroxy progesterone caproate) in environmental waters was developed by coupling solid-phase disk extraction (SPDE) to ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) with electrospray ionization. Among three types of extraction tested (C(8) SPDE, C(18) SPDE and C(18) SPE), the most satisfactory result was achieved using C(18) SPDE for its satisfactory recovery (75.6 to 101.4%) and short extraction time (15 min for 1 L deionised water). The validity of this method was investigated and good analytical performance for all the analytes was obtained, including low limits of method detection (0.5-3.4 ng/L) and excellent linear dynamic range (1.0-50.0 ng/L). The method was applied to determine the steroidal hormones in 10 environmental waters including tap water, river water, lake water and waste water in Beijing. No progestogen was detected in all samples and estrone, estriol, 17 alpha-ethynylestradiol were found in most samples at levels between 1.8 and 127.9 ng/L. (C) 2009 Elsevier B.V. All rights reserved.
WOS记录号	WOS:000267557800010
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/21565]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Sun, Li,Yong, Wei,Chu, Xiaogan,et al. Simultaneous determination of 15 steroidal oral contraceptives in water using solid-phase disk extraction followed by high performance liquid chromatography-tandem mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY A,2009,1216(28):5416-5423.
APA	Sun, Li,Yong, Wei,Chu, Xiaogan,&Lin, Jin-Ming.(2009).Simultaneous determination of 15 steroidal oral contraceptives in water using solid-phase disk extraction followed by high performance liquid chromatography-tandem mass spectrometry.JOURNAL OF CHROMATOGRAPHY A,1216(28),5416-5423.
MLA	Sun, Li,et al."Simultaneous determination of 15 steroidal oral contraceptives in water using solid-phase disk extraction followed by high performance liquid chromatography-tandem mass spectrometry".JOURNAL OF CHROMATOGRAPHY A 1216.28(2009):5416-5423.