Effects of nanoscale quantum dots in male Chinese loaches (Misgurnus anguillicaudatus): Estrogenic interference action, toxicokinetics and oxidative stress

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Effects of nanoscale quantum dots in male Chinese loaches (Misgurnus anguillicaudatus): Estrogenic interference action, toxicokinetics and oxidative stress
	Li HongCheng; Luo WenRu; Tao Yong; Wu Yuan; Lv XueFei; Zhou QunFang; Jiang GuiBin
刊名	SCIENCE IN CHINA SERIES B-CHEMISTRY
	2009-10
卷号	52 期号:10 页码:1683-1690
关键词	quantum dot estrogenic effect toxicokinetics oxidative stress
中文摘要	Quantum dots (QDs) have received more and more attention as a novel example of nanocrystals due to their unique fluorescent characteristics. Recently, the toxicity and the potential environmental effects of QDs have become a research hotspot. In this work, in vivo endocrine disrupting effect, toxicokinetics and oxidative stress of QDs were characterized following the intraperitoneal dosing in Chinese loaches. Vitellogenin (Vtg) levels induced by E2 decreased significantly when administrated with the mixture of QDs and E2, which was consistent with the observations of histopathology in testes. The release of free Cd(2+) from QDs and the non-specific adsorption of E2 by QDs might be the joint factors contributing to the inhibition of Vtg expression induced by E2 in the male Chinese loaches. In the muscle, bone, intestines, blood and testis, CdSe QDs reached the maximal concentration (C(max)) in approximately 1-h postinjection and subsequently presented downtrend with the prolonged time. Whereas, there were even increasing tendencies of CdSe QDs' concentrations in the liver and kidney. It is educible that CdSe QDs can be persistent at least for 7 days, indicating the overall half-life of CdSe QDs in the fish body is very long. The measurement of hepatic superoxide dismutase (SOD) activity and reduced glutathione (GSH) content indicate that QDs have smaller effects on the antioxidative system of the organisms compared with free Cd(2+) due to the effective prevention of the release of Cd by PEG coating of QDs. The comprehensive evaluation of QDs' toxicity in the present study provides an essential and general framework towards more focused research on the elucidation of the biological effects of QDs in vivo.
WOS记录号	WOS:000271168500020
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/21495]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Li HongCheng,Luo WenRu,Tao Yong,et al. Effects of nanoscale quantum dots in male Chinese loaches (Misgurnus anguillicaudatus): Estrogenic interference action, toxicokinetics and oxidative stress[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2009,52(10):1683-1690.
APA	Li HongCheng.,Luo WenRu.,Tao Yong.,Wu Yuan.,Lv XueFei.,...&Jiang GuiBin.(2009).Effects of nanoscale quantum dots in male Chinese loaches (Misgurnus anguillicaudatus): Estrogenic interference action, toxicokinetics and oxidative stress.SCIENCE IN CHINA SERIES B-CHEMISTRY,52(10),1683-1690.
MLA	Li HongCheng,et al."Effects of nanoscale quantum dots in male Chinese loaches (Misgurnus anguillicaudatus): Estrogenic interference action, toxicokinetics and oxidative stress".SCIENCE IN CHINA SERIES B-CHEMISTRY 52.10(2009):1683-1690.