Amplitude Modulation Mode of Scanning Ion Conductance Microscopy

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	Amplitude Modulation Mode of Scanning Ion Conductance Microscopy
	Li P(李鹏); Liu LQ(刘连庆); Yang Y(杨洋); Zhou L(周磊); Wang D(王栋); Wang YC(王越超); Li GY(李广勇)
刊名	Journal of Laboratory Automation
	2015
卷号	20 期号:4 页码:457-462
关键词	scanning ion conductance microscopy AM mode AC voltage capacitance compensation nanoscale imaging
ISSN号	2211-0682
通讯作者	刘连庆 ; 李广勇
产权排序	1
中文摘要	Live-cell imaging at the nanoscale resolution is a hot research topic in the field of life sciences for the direct observation of cellular biological activity. Scanning ion conductance microscopy (SICM) is one of the few effective imaging tools for live-cell imaging at the nanoscale resolution. However, there are various problems in existing scanning modes. The hopping and AC modes suffer from low speed, whereas the DC mode is prone to instability because of the DC drift and external electrical interference. In this article, we propose an amplitude modulation (AM) mode of SICM, which employs an AC voltage to enhance the stability and improve the scanning speed. In this AM mode, we introduce a capacitance compensation method to eliminate capacitance effect and use the amplitude of the AC current component to control the tip movement. Experimental results on polydimethylsiloxane samples verify the validity of the AM mode and demonstrate an improved performance of both speed and stability of this new mode.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]	Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]	ATOMIC-FORCE MICROSCOPY ; NANOSCALE ; CELLS ; AFM
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000358333800012
内容类型	期刊论文
源URL	[http://ir.sia.cn/handle/173321/16852]
专题	沈阳自动化研究所_机器人学研究室
推荐引用方式 GB/T 7714	Li P,Liu LQ,Yang Y,et al. Amplitude Modulation Mode of Scanning Ion Conductance Microscopy[J]. Journal of Laboratory Automation,2015,20(4):457-462.
APA	Li P.,Liu LQ.,Yang Y.,Zhou L.,Wang D.,...&Li GY.(2015).Amplitude Modulation Mode of Scanning Ion Conductance Microscopy.Journal of Laboratory Automation,20(4),457-462.
MLA	Li P,et al."Amplitude Modulation Mode of Scanning Ion Conductance Microscopy".Journal of Laboratory Automation 20.4(2015):457-462.