Roles of BDNF, dopamine D-3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization

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	Roles of BDNF, dopamine D-3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization
	Liang, Jing1 ; Zheng, Xigeng1 ; Chen, Jihuan 2; Li, Yingying1,3 ; Xing, Xiaoli1,3 ; Bai, Yunjing1 ; Li, Yingcong1
刊名	EUROPEAN NEUROPSYCHOPHARMACOLOGY
	2011-11-01
卷号	21 期号:11 页码:825-834
关键词	BDNF Dopamine D-3 receptor Morphine Nucleus accumbens Sensitization
ISSN号	0924-977X
通讯作者	Zheng, XG (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
产权排序	1
英文摘要	Drug seeking, craving, and relapse can be triggered by environmental stimuli that acquire motivational salience through repeated associations with the drug's effects. Previous studies indicated that the dopamine D-3 receptor (Drd3) might be involved in the expression of drug-conditioned responses in rats, and brain-derived neurotrophic factor (BDNF) could modulate Drd3 expression in the nucleus accumbens (NAc). However, the involvement of neural regions with Drd3 activation and the underlying interaction between BDNF and Drd3 in the expression of behavioral responses controlled by a drug-associated environment have remained poorly understood. The present study used a conditioning procedure to assess the roles of BDNF, Drd3, and their interactions in the NAc in the expression of morphine-induced context-specific locomotor sensitization. We showed that the expression of locomotor sensitization in the morphine-paired environment was accompanied by significantly increased expression of Drd3 mRNA and BDNF mRNA and protein levels. Both sensitized locomotion in morphine-paired rats and enhanced Drd3 mRNA were suppressed by intra-NAc infusion of anti-tyrosine kinase receptor B (TrkB) IgG. Furthermore, intra-NAc infusion of the Drd3-selective antagonist SB-277011A significantly decreased the expression of context-specific locomotor sensitization and upregulated BDNF mRNA. Altogether, these results suggest that BDNF/TrkB signaling and activation of Drd3 in the NAc are required for the expression of morphine-induced context-specific locomotor sensitization. (C) 2011 Elsevier B.V. and ECNP. All rights reserved.
学科主题	Cognitive neuroscience
收录类别	SCI
项目简介	This work was supported by grants from the National Natural Science Foundation of China (30900400, 30770722), the National Basic Research Program of China (2009CB522002) and the Project for Young Scientists Fund, Institute of Psychology, Chinese Academy of Sciences (08CX053005). These grants had no further role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
原文出处	http://ac.els-cdn.com/S0924977X11000022/1-s2.0-S0924977X11000022-main.pdf?_tid=babc61a6-ce03-11e4-87d5-00000aab0f6b&acdnat=1426747794_f30bdf8fbbffb0eb4b821d79dc190eab
语种	英语
WOS记录号	WOS:000296683300006
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/13252]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Scripps Res Inst, Mol & Integrat Neurosci Dept, La Jolla, CA 92037 USA 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liang, Jing,Zheng, Xigeng,Chen, Jihuan,et al. Roles of BDNF, dopamine D-3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY,2011,21(11):825-834.
APA	Liang, Jing.,Zheng, Xigeng.,Chen, Jihuan.,Li, Yingying.,Xing, Xiaoli.,...&Li, Yingcong.(2011).Roles of BDNF, dopamine D-3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization.EUROPEAN NEUROPSYCHOPHARMACOLOGY,21(11),825-834.
MLA	Liang, Jing,et al."Roles of BDNF, dopamine D-3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization".EUROPEAN NEUROPSYCHOPHARMACOLOGY 21.11(2011):825-834.