Multilocus association mapping using generalized ridge logistic regression | |
Liu, Zhe2; Shen, Yuanyuan3; Ott, Jurg1 | |
刊名 | BMC BIOINFORMATICS
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2011-09-29 | |
卷号 | 12 |
ISSN号 | 1471-2105 |
通讯作者 | Ott, J (reprint author), Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 4A Datun Rd, Beijing 100101, Peoples R China. |
产权排序 | 3 |
英文摘要 | Background: In genome-wide association studies, it is widely accepted that multilocus methods are more powerful than testing single-nucleotide polymorphisms (SNPs) one at a time. Among statistical approaches considering many predictors simultaneously, scan statistics are an effective tool for detecting susceptibility genomic regions and mapping disease genes. In this study, inspired by the idea of scan statistics, we propose a novel sliding window-based method for identifying a parsimonious subset of contiguous SNPs that best predict disease status. |
学科主题 | Physiological psychology/Biological Psychology |
收录类别 | SCI |
项目简介 | This work has been supported by NSFC grants from the Chinese government (project numbers 30730057 and 30700442) to JO. |
原文出处 | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224109/pdf/1471-2105-12-384.pdf |
语种 | 英语 |
WOS记录号 | WOS:000295848700001 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/12862] ![]() |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
作者单位 | 1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 2.Univ Chicago, Dept Stat, Chicago, IL 60637 USA 3.Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA |
推荐引用方式 GB/T 7714 | Liu, Zhe,Shen, Yuanyuan,Ott, Jurg. Multilocus association mapping using generalized ridge logistic regression[J]. BMC BIOINFORMATICS,2011,12. |
APA | Liu, Zhe,Shen, Yuanyuan,&Ott, Jurg.(2011).Multilocus association mapping using generalized ridge logistic regression.BMC BIOINFORMATICS,12. |
MLA | Liu, Zhe,et al."Multilocus association mapping using generalized ridge logistic regression".BMC BIOINFORMATICS 12(2011). |
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