Kringle 1 of human hepatocyte growth factor inhibits bovine aortic endothelial cell proliferation stimulated by basic fibroblast growth factor and causes cell apoptosis

	Kringle 1 of human hepatocyte growth factor inhibits bovine aortic endothelial cell proliferation stimulated by basic fibroblast growth factor and causes cell apoptosis
	Xin, L; Xu, R; Zhang, Q; Li, TP; Gan, RB
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2000
卷号	277 期号:1 页码:186-190
关键词	kringle hepatocyte growth factor angiostatin angiogenesis inhibitor apoptosis
通讯作者	Gan, RB (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, POB 55,320 Yue Yang Rd, Shanghai 200031, Peoples R China.,
英文摘要	Hepatocyte growth factor (HGF), also known as scatter factor, is a mesenchymal or stromal-derived mediator with angiogenic activity. There are four kringle domains in its amino terminus. They display considerable sequence similarity with those of angiostatin, an angiogenesis inhibitor. We now describe that the recombinant kringle1 of HGF (HGFK1) inhibits bovine aortic endothelial (BAE) cell proliferation stimulated by basic fibroblast growth factor in a dose-dependent manner, with an ED50 of approximately 0.7 mug/ml, while ED50 of angiostatin is 3 mug/ml, Treatment of BAE cell with HGFK1 caused cell apoptosis, This report thus constitutes the first demonstration that kringle1 of HGF is a selective inhibitor for BAE cell proliferation stimulated by bFGF. (C) 2000 Academic Press.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	HUMAN ANGIOSTATIN ; ANGIOGENESIS ; APOLIPOPROTEIN(A) ; EXPRESSION
收录类别	SCI
语种	英语
WOS记录号	WOS:000090070400032
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2736]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Xin, L,Xu, R,Zhang, Q,et al. Kringle 1 of human hepatocyte growth factor inhibits bovine aortic endothelial cell proliferation stimulated by basic fibroblast growth factor and causes cell apoptosis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2000,277(1):186-190.
APA	Xin, L,Xu, R,Zhang, Q,Li, TP,&Gan, RB.(2000).Kringle 1 of human hepatocyte growth factor inhibits bovine aortic endothelial cell proliferation stimulated by basic fibroblast growth factor and causes cell apoptosis.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,277(1),186-190.
MLA	Xin, L,et al."Kringle 1 of human hepatocyte growth factor inhibits bovine aortic endothelial cell proliferation stimulated by basic fibroblast growth factor and causes cell apoptosis".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 277.1(2000):186-190.