Mouse nestin protein localizes in growth cones of P19 neurons and cerebellar granule cells

	Mouse nestin protein localizes in growth cones of P19 neurons and cerebellar granule cells
	Yan, Y; Yang, J; Bian, W; Jing, NH
刊名	NEUROSCIENCE LETTERS
	2001
卷号	302 期号:1 页码:89-92
关键词	growth cone nestin growth-associated protein-43 P19 neurons cerebellar granule cells
通讯作者	Jing, NH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,
英文摘要	The neuronal growth cone, a highly motile structure at the distal tip of growing axons, contains filamentous actin and microtubules as its main cytoskeletal components. Using immunocytochemistry, we observed that nestin, which is the predominant intermediate filament protein in neuroepithelial cells and young neurons of the developing brain, appears to be strongly expressed in neurites and growth cones of neurons differentiating from P19 embryonic carcinoma cells in vitro. Double-staining of nestin and microtubule-associated protein-2 as well as nestin and growth-associated protein-43 revealed that nestin protein localizes in neurites and the central regions of growth cones of primary cultures of cerebellar granule cells from postnatal day 6 mice. These results suggest a role for nestin in growth cone guidance during axon elongation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
学科主题	Neurosciences & Neurology
类目[WOS]	Neurosciences
关键词[WOS]	INTERMEDIATE FILAMENT PROTEIN ; ORGANIZATION ; NEUROFILAMENT ; IDENTIFICATION ; EXPRESSION ; ELONGATION ; DYNAMICS ; GUIDANCE ; SYSTEM ; ACTIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000168139600007
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2729]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Yan, Y,Yang, J,Bian, W,et al. Mouse nestin protein localizes in growth cones of P19 neurons and cerebellar granule cells[J]. NEUROSCIENCE LETTERS,2001,302(1):89-92.
APA	Yan, Y,Yang, J,Bian, W,&Jing, NH.(2001).Mouse nestin protein localizes in growth cones of P19 neurons and cerebellar granule cells.NEUROSCIENCE LETTERS,302(1),89-92.
MLA	Yan, Y,et al."Mouse nestin protein localizes in growth cones of P19 neurons and cerebellar granule cells".NEUROSCIENCE LETTERS 302.1(2001):89-92.