Phorbol ester induces formation of a new phospholipase D product

	Phorbol ester induces formation of a new phospholipase D product
	Chai, MQ; Chen, JS; Song, JG
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2001
卷号	33 期号:4 页码:395-400
关键词	phospholipase D protein kinase C sphingolipid sphingomyclinase
通讯作者	,
英文摘要	It is demonstrated here that phorbol-12-myristate-13-acetate (PMA) induced the formation of a butanolated-sphingolipids in A-549 cells. In cells labeled with [H-3]-serine, the distribution of the radioactivity was easily found in phosphatidylcholine (PC), phosphatidylserine ( PS) and phosphatidylethanolamine ( PE), but not in phosphatidic acid (PA) and its immediate metabolic derivatives, suggesting that the newly detected PLD products were derived from sphingolipids and were different front the conventional product of PLD. Protein kinase C (PKC) inhibitors or PKC down-regulation by prolonged PMA treatment inhibited the PMA-induced generation of this butanolated-sphingolipid, indicating that PKC activation was required in this process.
学科主题	Biochemistry & Molecular Biology ; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	PROTEIN-KINASE-C ; SIGNAL-TRANSDUCTION ; GROWTH-FACTOR ; CROSS-TALK ; CELLS ; INHIBITION ; ACTIVATION ; BETA ; LYSOPHOSPHATIDATE ; PHOSPHATIDATE
收录类别	SCI
语种	中文
WOS记录号	WOS:000170070500006
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2648]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Chai, MQ,Chen, JS,Song, JG. Phorbol ester induces formation of a new phospholipase D product[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2001,33(4):395-400.
APA	Chai, MQ,Chen, JS,&Song, JG.(2001).Phorbol ester induces formation of a new phospholipase D product.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,33(4),395-400.
MLA	Chai, MQ,et al."Phorbol ester induces formation of a new phospholipase D product".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 33.4(2001):395-400.