The involvement of p38 MAPK in transforming growth factor beta 1-induced apoptosis in murine hepatocytes

	The involvement of p38 MAPK in transforming growth factor beta 1-induced apoptosis in murine hepatocytes
	Liao, JH; Chen, JS; Chai, MQ; Zhao, S; Song, JG
刊名	CELL RESEARCH
	2001
卷号	11 期号:2 页码:89-94
关键词	transforming growth factor beta apoptosis p38 hepatocyte signal transduction
通讯作者	Song, JG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,
英文摘要	We reported in this manuscript that TGF-beta1 induces apoptosis in AML12 murine hepatocytes, which is associated with the activation of p38 MAPK signaling pathway. SB202190, a specific inhibitor of p38 MAPK, strongly inhibited the TGF-beta1-induced apoptosis and PAI-1 promoter activity. Treatment of cells with TGF-beta1 activates p38. Furthermore, over-expression of dominant negative mutant p38 also reduced the TGF-beta1-induced apoptosis. The data indicate that the activation of p38 is involved in TGF-beta1-mediated gene expression and apoptosis.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	ACTIVATED PROTEIN-KINASE ; BETA SIGNAL-TRANSDUCTION ; HEPATOMA-CELL LINE ; TGF-BETA ; EPITHELIAL-CELLS ; DOWN-REGULATION ; INDUCTION ; EXPRESSION ; PATHWAY ; CASPASE
收录类别	SCI
语种	英语
WOS记录号	WOS:000169787000002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2597]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Liao, JH,Chen, JS,Chai, MQ,et al. The involvement of p38 MAPK in transforming growth factor beta 1-induced apoptosis in murine hepatocytes[J]. CELL RESEARCH,2001,11(2):89-94.
APA	Liao, JH,Chen, JS,Chai, MQ,Zhao, S,&Song, JG.(2001).The involvement of p38 MAPK in transforming growth factor beta 1-induced apoptosis in murine hepatocytes.CELL RESEARCH,11(2),89-94.
MLA	Liao, JH,et al."The involvement of p38 MAPK in transforming growth factor beta 1-induced apoptosis in murine hepatocytes".CELL RESEARCH 11.2(2001):89-94.