Directional migration of leukocytes: their pathological roles in inflammation and strategies for development of anti-inflammatory therapies

	Directional migration of leukocytes: their pathological roles in inflammation and strategies for development of anti-inflammatory therapies
	Geng, JG
刊名	CELL RESEARCH
	2001
卷号	11 期号:2 页码:85-88
关键词	directional cell migration leukocytes inflammation therapy
通讯作者	Geng, JG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,
英文摘要	Directional migration of leukocytes is indispensable to innate immunity for host defense. However, recruitment of leukocytes to a site of tissue injury also constitutes a leading cause for inflammatory responses. Mechanistically, it involves a cascade of cellular events precisely regulated by temporal and spatial presentation of a repertoire of molecules in the migrating leukocytes and their surroundings (microenvironments). Here I will summarize the emerging evidence that has shed lights on the underlying molecular mechanism for directional migration of leukocytes, which has guided the therapeutical development for innovative anti-inflammatory medicines.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	NF-KAPPA-B ; P-SELECTIN ; NONANTICOAGULANT HEPARIN ; ADHESION MOLECULES ; CELL-MIGRATION ; LECTIN DOMAIN ; CHEMOKINES ; MECHANISMS ; LIGAND ; SIALOGLYCOPROTEIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000169787000001
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2596]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Geng, JG. Directional migration of leukocytes: their pathological roles in inflammation and strategies for development of anti-inflammatory therapies[J]. CELL RESEARCH,2001,11(2):85-88.
APA	Geng, JG.(2001).Directional migration of leukocytes: their pathological roles in inflammation and strategies for development of anti-inflammatory therapies.CELL RESEARCH,11(2),85-88.
MLA	Geng, JG."Directional migration of leukocytes: their pathological roles in inflammation and strategies for development of anti-inflammatory therapies".CELL RESEARCH 11.2(2001):85-88.