Attenuation of morphine dependence and withdrawal in rats by venlafaxine, a serotonin and noradrenaline reuptake inhibitor

	Attenuation of morphine dependence and withdrawal in rats by venlafaxine, a serotonin and noradrenaline reuptake inhibitor
	Lu, L; Su, WJ; Yue, W; Ge, X; Su, F; Pei, G; Ma, L
刊名	LIFE SCIENCES
	2001
卷号	69 期号:1 页码:37-46
关键词	serotonin/noradrenaline reuptake inhibitor opiate dependence withdrawal conditioned place preference relapse
通讯作者	Ma, L (reprint author), Fudan Univ, Med Ctr, Natl Lab Med Neurobiol, 138 Yi Xue Yuan Rd, Shanghai 200032, Peoples R China.,
英文摘要	The effects of venlafaxine, a novel serotonin and adrenaline reuptake inhibitor, on the morphine withdrawal and activation of morphine conditioned place preference (CPP), were investigated in rats. Our results showed that the most morphine withdrawal signs, including jumping, writhing, shakes, exploring, lacrimation, piloerection, irritability, and diarrhea, were attenuated by pretreatment with 10 or 20 mg/kg venlafaxine. To investigate the effects of venlafaxine on relapse to opiate dependence, the morphine CPP was used and a dopamine D2 antagonist sulpiride was selected as a control drug. The morphine CPP disappeared following a 28-day drug-free period and appeared again after given a single injection of 1 mg/kg morphine. Acute treatment with sulpiride (25 or 50 mg/kg, i.p.) 30 min prior to 1 mg/kg morphine injection significantly blocked the reacquisition of CPP, while venlafaxine (10 or 20 mg/kg, i.p.) did not show significant effect. However, chronic treatment with venlafaxine (5 or 10 mg/kg, i.p. twice, daily, for seven consecutive days) significantly attenuated the reacquisition of morphine CPP, whereas chronic treatment with sulpiride (10 or 20 mg/kg, i.p.) have no significant effect. Our results demonstrated for the first time that venlafaxine strongly attenuates morphine withdrawal and morphine-induced reaquisition of CPP in rats and suggest that venlafaxine. an effective novel antidepressive drug, may have therapeutic potential in treatment and prevention of relapse to opiate dependence. (C) 2001 Elsevier Science Inc. All rights reserved.
学科主题	Research & Experimental Medicine; Pharmacology & Pharmacy
类目[WOS]	Medicine, Research & Experimental ; Pharmacology & Pharmacy
关键词[WOS]	CORTICOTROPIN-RELEASING FACTOR ; STRESS-INDUCED RELAPSE ; ANTAGONIST ; COCAINE ; OPIATE ; SEEKING ; MICE
收录类别	SCI
语种	英语
WOS记录号	WOS:000169028500004
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2576]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Lu, L,Su, WJ,Yue, W,et al. Attenuation of morphine dependence and withdrawal in rats by venlafaxine, a serotonin and noradrenaline reuptake inhibitor[J]. LIFE SCIENCES,2001,69(1):37-46.
APA	Lu, L.,Su, WJ.,Yue, W.,Ge, X.,Su, F.,...&Ma, L.(2001).Attenuation of morphine dependence and withdrawal in rats by venlafaxine, a serotonin and noradrenaline reuptake inhibitor.LIFE SCIENCES,69(1),37-46.
MLA	Lu, L,et al."Attenuation of morphine dependence and withdrawal in rats by venlafaxine, a serotonin and noradrenaline reuptake inhibitor".LIFE SCIENCES 69.1(2001):37-46.