Crystal structure of a human rhinovirus that displays part of the HIV-1V3 loop and induces neutralizing antibodies against HIV-1

	Crystal structure of a human rhinovirus that displays part of the HIV-1V3 loop and induces neutralizing antibodies against HIV-1
	Ding, JP; Smith, AD; Geisler, SC; Ma, XJ; Arnold, GF; Arnold, E
刊名	STRUCTURE
	2002
卷号	10 期号:7 页码:999-1011
通讯作者	Arnold, E (reprint author), Rutgers State Univ, CABM, 679 Hoes Lane, Piscataway, NJ 08854 USA.,
英文摘要	We report the 2.7 Angstrom resolution structure of a chimeric rhinovirus, MN-III-2, that displays part of the HIV-1 gp120 V3 loop and elicits HIV-neutralizing antibodies. The V3 loop insert is dominated by two type 10 turns. The structures of two adjacent tripeptides resemble those of analogous segments in three FabN3 loop peptide complexes. Although two of the three corresponding antibodies bind and neutralize MN-III-2 well, only one of the three can bind without significant rearrangement. These results suggest that the V3 loop insert: (1) can share some local conformational similarity to V3 loop sequences presented on different structural frameworks; (2) must be able to adopt multiple conformations, even in a relatively constrained environment; and (3) may mimic the conformational variability of the epitope on HIV-1, increasing the likelihood of eliciting appropriate neutralizing immune responses.
学科主题	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]	HUMAN-IMMUNODEFICIENCY-VIRUS ; GP120 ENVELOPE GLYCOPROTEIN ; COMMON COLD VIRUS ; V3 LOOP ; MONOCLONAL-ANTIBODY ; ANGSTROM RESOLUTION ; CHEMOKINE RECEPTORS ; NMR STRUCTURE ; TYPE-1 ; PEPTIDE
收录类别	SCI
语种	英语
WOS记录号	WOS:000176603300014
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2525]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Ding, JP,Smith, AD,Geisler, SC,et al. Crystal structure of a human rhinovirus that displays part of the HIV-1V3 loop and induces neutralizing antibodies against HIV-1[J]. STRUCTURE,2002,10(7):999-1011.
APA	Ding, JP,Smith, AD,Geisler, SC,Ma, XJ,Arnold, GF,&Arnold, E.(2002).Crystal structure of a human rhinovirus that displays part of the HIV-1V3 loop and induces neutralizing antibodies against HIV-1.STRUCTURE,10(7),999-1011.
MLA	Ding, JP,et al."Crystal structure of a human rhinovirus that displays part of the HIV-1V3 loop and induces neutralizing antibodies against HIV-1".STRUCTURE 10.7(2002):999-1011.