Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells

	Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells
	Yang, L; He, HY; Zhang, XJ
刊名	NEUROSCIENCE RESEARCH
	2002
卷号	42 期号:4 页码:261-268
关键词	acetylcholinesterase Alzheimer's disease apoptosis caspase-3
通讯作者	Zhang, XJ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,
英文摘要	Programmed cell death plays an integral role in neurodegenerative diseases such as Alzheimer's disease (AD). Acetylcholinesterase (AChE) was suggested to be neurotoxic in vivo and in vitro and accelerate assembly of amyloid peptide into Alzheimer's fibrils. In our experiments, we found increased AChE expression in apoptotic neuroblastoma SK-N-SH cells after long-term culture. Our results first showed that in apoptotic SK-N-SH cells, AChE aggregated in the nucleus and suppression of AChE expression with antisense oligonucleotide could save the cells from apoptosis. It was also found that caspase-3 activity was parallel with AChE activation in apoptotic SK-N-SH cells. These results suggest that AChE plays an important role in the procession of neuroblastoma cell apoptosis and favor the association between AChE and neuronal apoptosis in AD. (C) 2002 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
学科主题	Neurosciences & Neurology
类目[WOS]	Neurosciences
关键词[WOS]	AMYLOID-BETA-PEPTIDE ; HUMAN PRIMARY NEURON ; ALZHEIMERS-DISEASE ; PRECURSOR PROTEIN ; NERVOUS-SYSTEM ; ACETYLCHOLINESTERASE ; CHOLINESTERASES ; BRAIN ; NEUROTOXICITY ; MECHANISMS
收录类别	SCI
语种	英语
WOS记录号	WOS:000175442000003
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2491]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Yang, L,He, HY,Zhang, XJ. Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells[J]. NEUROSCIENCE RESEARCH,2002,42(4):261-268.
APA	Yang, L,He, HY,&Zhang, XJ.(2002).Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells.NEUROSCIENCE RESEARCH,42(4),261-268.
MLA	Yang, L,et al."Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells".NEUROSCIENCE RESEARCH 42.4(2002):261-268.