Stage-specific expression of breast cancer-specific gene gamma-synuclein

	Stage-specific expression of breast cancer-specific gene gamma-synuclein
	Wu, KJ; Weng, ZY; Tao, QH; Lin, GF; Wu, XR; Qian, HQ; Zhang, YC; Ding, XY; Jiang, YF; Shi, YE
刊名	CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
	2003
卷号	12 期号:9 页码:920-925
通讯作者	Shi, YE (reprint author), Albert Einstein Coll Med, Long Isl Jewish Med Ctr, Dept Radiat Oncol, New Hyde Pk, NY 11040 USA.,
英文摘要	gamma-Synuclein (SNCG), also referred, as breast cancer-specific gene 1, is the third member of a neuronal protein family synuclein. SNCG is highly expressed in human-infiltrating breast carcinomas but not expressed in normal or benign breast tissues. To evaluate the clinical relevance of SNCG expression in breast cancer progression and its correlation with clinical parameters, we analyzed SNCG expression in 79 clinical breast specimens from primary breast cancer, hyperplasia, and fibroadenoma patients by reverse transcription-PCR. The status of estrogen receptor, progesterone receptor, proliferating cell nuclear antigen, and C-erBb2 was also analyzed by immunohistochemistry. Overall SNCG mRNA expression was detectable in 38.8% of breast cancers. However, 79% of stage III/IV breast cancers were positive for SNCG expression, whereas only 15% of stage I/II breast cancers were positive for SNCG expression. In contrast, the expression of SNCG was undetectable in all benign breast lesions. The expression of SNCG was strongly correlated to the stage of breast cancer (P = 0.000). This study suggests that the expression of SNCG is stage specific for breast cancer. SNCG is expected to be a useful marker for breast cancer progression and a potential target for breast cancer treatment.
学科主题	Oncology; Public, Environmental & Occupational Health
类目[WOS]	Oncology ; Public, Environmental & Occupational Health
关键词[WOS]	INHIBITOR-RELATED GENE ; PARKINSONS-DISEASE ; ALZHEIMER-DISEASE ; GROWTH INHIBITOR ; ALPHA-SYNUCLEIN ; CELLS ; IDENTIFICATION ; SUPPRESSION ; METASTASIS ; MECHANISMS
收录类别	SCI
语种	英语
WOS记录号	WOS:000185467900017
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2347]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Wu, KJ,Weng, ZY,Tao, QH,et al. Stage-specific expression of breast cancer-specific gene gamma-synuclein[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,2003,12(9):920-925.
APA	Wu, KJ.,Weng, ZY.,Tao, QH.,Lin, GF.,Wu, XR.,...&Shi, YE.(2003).Stage-specific expression of breast cancer-specific gene gamma-synuclein.CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,12(9),920-925.
MLA	Wu, KJ,et al."Stage-specific expression of breast cancer-specific gene gamma-synuclein".CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 12.9(2003):920-925.