Overexpression of STAT3 in COS7 cells causes prominent morphological changes

	Overexpression of STAT3 in COS7 cells causes prominent morphological changes
	Yan, Y; Xia, CH; Cao, XM; Jing, NH
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2003
卷号	35 期号:8 页码:717-722
关键词	COS7 cell Stat3 overexpression cell morphology reporter gene
通讯作者	Jing, NH (reprint author), Chinese Acad Sci, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,
英文摘要	Signal transducer and activator of transcription 3 (STAT3) plays a central role in mediating signals related to cell growth, differentiation, survival and movement. In this report, the results of immunocytochemistry and Western blot analysis showed that the active form of Stat3 protein existed in COS7 cells. The endogenous Stat3 protein could also induce the expression of m67-sequence-directed reporter genes. The transient transfection of StaB cDNA into COS7 cells increased Stat3 protein level and the expression of the reporter gene. The overexpression of Stat3 protein in COS7 cells caused prominent cell morphological changes. These cells had a much larger cell body, extended long processes with branches, lamellipodia and filopodia. These results suggest that Stat3 protein may, play important roles in cell adhension, migration and cytoskeleton reorganization.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	SIGNALING PATHWAY ; GROWTH ; GENE ; ACTIVATION ; FAMILY ; MOUSE ; ROLES ; DIFFERENTIATION ; EXPRESSION ; RESPONSES
收录类别	SCI
语种	中文
WOS记录号	WOS:000184988600006
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2329]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Yan, Y,Xia, CH,Cao, XM,et al. Overexpression of STAT3 in COS7 cells causes prominent morphological changes[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2003,35(8):717-722.
APA	Yan, Y,Xia, CH,Cao, XM,&Jing, NH.(2003).Overexpression of STAT3 in COS7 cells causes prominent morphological changes.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,35(8),717-722.
MLA	Yan, Y,et al."Overexpression of STAT3 in COS7 cells causes prominent morphological changes".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 35.8(2003):717-722.