Progress on conotoxins

	Progress on conotoxins
	Wang, CZ; Jiang, H; Qi, ZW
刊名	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
	2003
卷号	30 期号:4 页码:537-545
关键词	active peptide conotoxin ion channel neurotransmitter receptor agonist antagonist
通讯作者	,
英文摘要	The venoms of predatory cone snails represent a rich combinatorial-like library of evolutionarily selected.. neuropharmacologically active peptides. A major fraction of the venom components are conotoxins-small, disulfide-rich peptides that potently and specifically interfere with neurotransmission by targeting a variety of proteins expressed on the cell surface, such as the ion channels of Ca2+, Na+ and K+, and the receptors of acetylcholine, 5-hydroxy tryptamine, NMDA, vasopressin and neurotensin. Because of low molecular mass, diversity of structure and targets, high specifiticy and tissue selectivity of conotoxins they have more advantages over other naturally occurring toxins. Conopeptides could be also used as tools in neuroscience or as therapeutic agents. The conopeptides characterized to date are estimated to represent only 0.1% of the total present in 500 known species of Conus, therefore many novel conotoxins remain to be elucidated and explored. Pharmaceutical companies are now utilizing Conus-derived peptides to develop novel medications for pain, epilepsy and other disorders.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	NICOTINIC ACETYLCHOLINE-RECEPTOR ; CONUS-PURPURASCENS VENOM ; CALCIUM-CHANNEL BLOCKER ; SODIUM-CHANNELS ; ION-CHANNEL ; OMEGA-CONOTOXIN ; MARINE SNAIL ; PEPTIDE ; FAMILY ; ANTAGONIST
收录类别	SCI
语种	中文
WOS记录号	WOS:000184947500009
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2278]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Wang, CZ,Jiang, H,Qi, ZW. Progress on conotoxins[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2003,30(4):537-545.
APA	Wang, CZ,Jiang, H,&Qi, ZW.(2003).Progress on conotoxins.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,30(4),537-545.
MLA	Wang, CZ,et al."Progress on conotoxins".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 30.4(2003):537-545.