Studies on the synthesis and RNA binding of ruthenium (II) polypyridine complexes

	Studies on the synthesis and RNA binding of ruthenium (II) polypyridine complexes
	Xu, H; Deng, H; Hu, HY; Liu, JZ; Chao, H; Liu, J; Ji, LN
刊名	CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
	2003
卷号	24 期号:1 页码:25-27
关键词	ruthenium( II ) polypyridine complex RNA interaction
通讯作者	Ji, LN (reprint author), Zhongshan Univ, Sch Chem & Chem Engn, Guangzhou 510275, Peoples R China.,
英文摘要	A new ruthenium polypyridine complex, [Ru(phen)(2)(pMIP)](2+)(phen=1,10-phenanthroline, pMIP=2-(4-methylphenyl)imidazo [4,5-f][1,10]phenanthroline), was synthesized and characterized by elementary analysis, MS and H-1 NMR. Spectroscopic methods have been carried out on the interaction mechanism,of the Ru (II) complex with yeast tRNA systematically. The experimental results indicate that the complex binds to yeast tRNA with an intercalative mode-possibly, and interacts with yeast tRNA enantioselectively. The experimental results also suggest that spectroscopic method is effective on studying the interaction mechanism of Ru (II) complexes with RNA. Information obtained from the study is potentially useful in the design of new RNA-targeting drugs.
学科主题	Chemistry
类目[WOS]	Chemistry, Multidisciplinary
关键词[WOS]	DNA
收录类别	SCI
语种	中文
WOS记录号	WOS:000182666400007
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2234]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Xu, H,Deng, H,Hu, HY,et al. Studies on the synthesis and RNA binding of ruthenium (II) polypyridine complexes[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2003,24(1):25-27.
APA	Xu, H.,Deng, H.,Hu, HY.,Liu, JZ.,Chao, H.,...&Ji, LN.(2003).Studies on the synthesis and RNA binding of ruthenium (II) polypyridine complexes.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,24(1),25-27.
MLA	Xu, H,et al."Studies on the synthesis and RNA binding of ruthenium (II) polypyridine complexes".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 24.1(2003):25-27.