IFN-gamma activates cAMP/PKA/CREB signaling pathway in murine peritoneal macrophages

	IFN-gamma activates cAMP/PKA/CREB signaling pathway in murine peritoneal macrophages
	Liu, L; Wang, Y; Fan, Y; Li, CL; Chang, ZL
刊名	JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
	2004
卷号	24 期号:6 页码:334-342
通讯作者	Chang, ZL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,musig@sunm.shcnc.ac.cn
英文摘要	Interferon-gamma (IFN-gamma) is a macrophage-activating cytokine that serves critical functions in innate and adaptive immunity and is thought to be mediated by the Jak-Stat signaling pathway. The present study establishes for the first time that cyclic adenosine monophosphate, protein kinase A, and cAMP response element-binding protein (cAMP/PKA/CREB) are coregulators of the IFN-gamma signaling pathway. Experimental data indicate that exogenous IFN-gamma stimulated cAMP accumulation and PKA activation in time-dependent and dose-dependent manners in murine peritoneal macrophages. Moreover, IFN-gamma stimulated CREB phosphorylation and CREB DNA binding, which could be significantly attenuated by PKA inhibition with H89. It appears that a novel cAMP/PKA/CREB signaling pathway is activated by IFN-gamma in macrophages, suggesting that an alternate signaling pathway exists in macrophages in response to IFN-gamma.
学科主题	Biochemistry & Molecular Biology; Cell Biology; Immunology
类目[WOS]	Biochemistry & Molecular Biology ; Cell Biology ; Immunology
关键词[WOS]	PROTEIN-KINASE-A ; ELEMENT-BINDING PROTEIN ; INDUCED GENE-EXPRESSION ; INTERFERON-GAMMA ; MAP KINASE ; P38 MAPK ; CREB ; PHOSPHORYLATION ; TRANSCRIPTION ; AMP
收录类别	SCI
语种	英语
WOS记录号	WOS:000222185400002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2101]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Liu, L,Wang, Y,Fan, Y,et al. IFN-gamma activates cAMP/PKA/CREB signaling pathway in murine peritoneal macrophages[J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH,2004,24(6):334-342.
APA	Liu, L,Wang, Y,Fan, Y,Li, CL,&Chang, ZL.(2004).IFN-gamma activates cAMP/PKA/CREB signaling pathway in murine peritoneal macrophages.JOURNAL OF INTERFERON AND CYTOKINE RESEARCH,24(6),334-342.
MLA	Liu, L,et al."IFN-gamma activates cAMP/PKA/CREB signaling pathway in murine peritoneal macrophages".JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 24.6(2004):334-342.