IFN-gamma activates cAMP/PKA/CREB signaling pathway in murine peritoneal macrophages | |
Liu, L; Wang, Y; Fan, Y; Li, CL; Chang, ZL | |
刊名 | JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
![]() |
2004 | |
卷号 | 24期号:6页码:334-342 |
通讯作者 | Chang, ZL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,musig@sunm.shcnc.ac.cn |
英文摘要 | Interferon-gamma (IFN-gamma) is a macrophage-activating cytokine that serves critical functions in innate and adaptive immunity and is thought to be mediated by the Jak-Stat signaling pathway. The present study establishes for the first time that cyclic adenosine monophosphate, protein kinase A, and cAMP response element-binding protein (cAMP/PKA/CREB) are coregulators of the IFN-gamma signaling pathway. Experimental data indicate that exogenous IFN-gamma stimulated cAMP accumulation and PKA activation in time-dependent and dose-dependent manners in murine peritoneal macrophages. Moreover, IFN-gamma stimulated CREB phosphorylation and CREB DNA binding, which could be significantly attenuated by PKA inhibition with H89. It appears that a novel cAMP/PKA/CREB signaling pathway is activated by IFN-gamma in macrophages, suggesting that an alternate signaling pathway exists in macrophages in response to IFN-gamma. |
学科主题 | Biochemistry & Molecular Biology; Cell Biology; Immunology |
类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology ; Immunology |
关键词[WOS] | PROTEIN-KINASE-A ; ELEMENT-BINDING PROTEIN ; INDUCED GENE-EXPRESSION ; INTERFERON-GAMMA ; MAP KINASE ; P38 MAPK ; CREB ; PHOSPHORYLATION ; TRANSCRIPTION ; AMP |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000222185400002 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/2101] ![]() |
专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
推荐引用方式 GB/T 7714 | Liu, L,Wang, Y,Fan, Y,et al. IFN-gamma activates cAMP/PKA/CREB signaling pathway in murine peritoneal macrophages[J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH,2004,24(6):334-342. |
APA | Liu, L,Wang, Y,Fan, Y,Li, CL,&Chang, ZL.(2004).IFN-gamma activates cAMP/PKA/CREB signaling pathway in murine peritoneal macrophages.JOURNAL OF INTERFERON AND CYTOKINE RESEARCH,24(6),334-342. |
MLA | Liu, L,et al."IFN-gamma activates cAMP/PKA/CREB signaling pathway in murine peritoneal macrophages".JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 24.6(2004):334-342. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论