Stat3 signaling is present and active during development of the central nervous system and eye of vertebrates

	Stat3 signaling is present and active during development of the central nervous system and eye of vertebrates
	Yan, Y; Bian, W; Xie, ZQ; Cao, XM; Le Roux, I; Guillemot, F; Jing, NH
刊名	DEVELOPMENTAL DYNAMICS
	2004
卷号	231 期号:2 页码:248-257
关键词	Stat3 pYStat3 central nervous system eye development in ovo electroporation mouse chick
通讯作者	Jing, NH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,njing@sibs.ac.cn
英文摘要	Stat3, a member of the signal transducer and activator of transcription (STAT) family, plays a central role in mediating cell growth, differentiation, and survival signals. In this report, we show that Stat3 immunoreactivity was localized to specific regions in the developing mouse brain, neural tube, and eye from embryonic day 10.5 to postnatal day 0. The active form of Stat3 protein, which is phosphorylated on tyrosine 705 (pYStat3), was also found in the developing neural tube with more restricted distribution. An in ovo chick embryo electroporation assay showed that the endogenous chick Stat3 could drive consensus sis-inducible element-directed reporter gene expression. These results demonstrate that the active Stat3 protein is present and might play a role during the development of the central nervous system and eye. (C) 2004 Wiley-Liss, Inc.
学科主题	Anatomy & Morphology; Developmental Biology
类目[WOS]	Anatomy & Morphology ; Developmental Biology
关键词[WOS]	LEUKEMIA INHIBITORY FACTOR ; SPINAL-CORD PRECURSORS ; FACTOR-RECEPTOR ; ASTROCYTE DIFFERENTIATION ; TARGETED DISRUPTION ; NEUROTROPHIC FACTOR ; NEURITE OUTGROWTH ; MOTOR-NEURONS ; GENE ; ACTIVATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000223883700002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/2031]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Yan, Y,Bian, W,Xie, ZQ,et al. Stat3 signaling is present and active during development of the central nervous system and eye of vertebrates[J]. DEVELOPMENTAL DYNAMICS,2004,231(2):248-257.
APA	Yan, Y.,Bian, W.,Xie, ZQ.,Cao, XM.,Le Roux, I.,...&Jing, NH.(2004).Stat3 signaling is present and active during development of the central nervous system and eye of vertebrates.DEVELOPMENTAL DYNAMICS,231(2),248-257.
MLA	Yan, Y,et al."Stat3 signaling is present and active during development of the central nervous system and eye of vertebrates".DEVELOPMENTAL DYNAMICS 231.2(2004):248-257.