Systemic delivery of full-length C/EBP beta/liposome complex suppresses growth of human colon cancer in nude mice | |
Sun, L; Fu, BB; Liu, DG | |
刊名 | CELL RESEARCH
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2005 | |
卷号 | 15期号:10页码:770-776 |
关键词 | tumor supression C/EBP beta colon cancer apoptosis |
通讯作者 | Liu, DG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,dgliu@sibs.ac.cn |
英文摘要 | C/EBP beta (CCAAT/enhancer-binding protein beta) is an important transcription factor involved in cellular proliferation and differentiation. Overexpression of the full-length C/EBP beta protein results in cellular growth arrest and apoptosis. Using a nonviral liposome as carrier, we delivered the full-length C/EBP beta expression plasmid, pCN, into nude mice bearing CW-2 human colon cancer tumors via tail vein. Southern blots revealed that the major organs and tumors were transfected. Experimental gene therapy showed that a strong suppression of tumor growth was observed in the pCN-treated mice, and such suppression was due to the overexpression of C/EBP beta, leading to the increased apoptosis in tumors of pCN-treated mice. No apparent toxic effects of pCN/liposome complex were observed in the animals. Thus, C/EBP beta has tumor suppression effect in vivo and may be used in gene therapy for cancers. |
学科主题 | Cell Biology |
类目[WOS] | Cell Biology |
关键词[WOS] | ENHANCER-BINDING-PROTEIN ; CELL-PROLIFERATION ; TRANSCRIPTIONAL ACTIVATOR ; INHIBITORY PROTEIN ; EPITHELIAL-CELLS/ ; COLORECTAL-CANCER ; INDUCED APOPTOSIS ; BREAST-CANCER ; MAMMARY-GLAND ; NF-IL6 GENE |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000233384600002 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/1959] ![]() |
专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
推荐引用方式 GB/T 7714 | Sun, L,Fu, BB,Liu, DG. Systemic delivery of full-length C/EBP beta/liposome complex suppresses growth of human colon cancer in nude mice[J]. CELL RESEARCH,2005,15(10):770-776. |
APA | Sun, L,Fu, BB,&Liu, DG.(2005).Systemic delivery of full-length C/EBP beta/liposome complex suppresses growth of human colon cancer in nude mice.CELL RESEARCH,15(10),770-776. |
MLA | Sun, L,et al."Systemic delivery of full-length C/EBP beta/liposome complex suppresses growth of human colon cancer in nude mice".CELL RESEARCH 15.10(2005):770-776. |
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