Systemic delivery of full-length C/EBP beta/liposome complex suppresses growth of human colon cancer in nude mice

	Systemic delivery of full-length C/EBP beta/liposome complex suppresses growth of human colon cancer in nude mice
	Sun, L; Fu, BB; Liu, DG
刊名	CELL RESEARCH
	2005
卷号	15 期号:10 页码:770-776
关键词	tumor supression C/EBP beta colon cancer apoptosis
通讯作者	Liu, DG (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,dgliu@sibs.ac.cn
英文摘要	C/EBP beta (CCAAT/enhancer-binding protein beta) is an important transcription factor involved in cellular proliferation and differentiation. Overexpression of the full-length C/EBP beta protein results in cellular growth arrest and apoptosis. Using a nonviral liposome as carrier, we delivered the full-length C/EBP beta expression plasmid, pCN, into nude mice bearing CW-2 human colon cancer tumors via tail vein. Southern blots revealed that the major organs and tumors were transfected. Experimental gene therapy showed that a strong suppression of tumor growth was observed in the pCN-treated mice, and such suppression was due to the overexpression of C/EBP beta, leading to the increased apoptosis in tumors of pCN-treated mice. No apparent toxic effects of pCN/liposome complex were observed in the animals. Thus, C/EBP beta has tumor suppression effect in vivo and may be used in gene therapy for cancers.
学科主题	Cell Biology
类目[WOS]	Cell Biology
关键词[WOS]	ENHANCER-BINDING-PROTEIN ; CELL-PROLIFERATION ; TRANSCRIPTIONAL ACTIVATOR ; INHIBITORY PROTEIN ; EPITHELIAL-CELLS/ ; COLORECTAL-CANCER ; INDUCED APOPTOSIS ; BREAST-CANCER ; MAMMARY-GLAND ; NF-IL6 GENE
收录类别	SCI
语种	英语
WOS记录号	WOS:000233384600002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1959]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Sun, L,Fu, BB,Liu, DG. Systemic delivery of full-length C/EBP beta/liposome complex suppresses growth of human colon cancer in nude mice[J]. CELL RESEARCH,2005,15(10):770-776.
APA	Sun, L,Fu, BB,&Liu, DG.(2005).Systemic delivery of full-length C/EBP beta/liposome complex suppresses growth of human colon cancer in nude mice.CELL RESEARCH,15(10),770-776.
MLA	Sun, L,et al."Systemic delivery of full-length C/EBP beta/liposome complex suppresses growth of human colon cancer in nude mice".CELL RESEARCH 15.10(2005):770-776.