Sequence diversity of T-superfamily conotoxins from Conus marmoreus

	Sequence diversity of T-superfamily conotoxins from Conus marmoreus
	Han, YH; Wang, Q; Jiang, H; Miao, XW; Chen, JS; Chi, CW
刊名	TOXICON
	2005
卷号	45 期号:4 页码:481-487
关键词	Conus marmroeus T-superfamily conotoxin cDNA cloning protein purification sequence diversity
通讯作者	Chi, CW (reprint author), Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Inst Biochem & Cell Biol, Grad Sch, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,chi@sunm.shcnc.ac.cn
英文摘要	Remarkable sequence diversity of T-superfamily conotoxins was found in a mollusk-hunting cone snail Conus marmoreus. The sequence of mr5a purified from the snail venom was determined, while six other sequences of Mr5.1a, Mr5.1b, Mr5.2, Mr5.3, Mr5.4a, and Mr5.4b were deduced from their corresponding cDNA cloned by RACE approach. mr5a of 10 amino acid residues is one of the shortest T-superfamily conotoxins ever found. They all share a typical (-CC-CC-) Cys pattern, a conserved signal peptide and a long 3'-untranslated region. A consensus Glu residue is preceded by the second two adjacent cysteines in all these toxins except in mr5a, whereas Mr5.1a, Mr5.1b, Mr5.4a and Mr5.4b are abundant in Trp residues. The identification of these highly divergent T-superfamily conotoxins will facilitate the understanding the relationship of their structure and function. (c) 2004 Elsevier Ltd. All rights reserved.
学科主题	Pharmacology & Pharmacy; Toxicology
类目[WOS]	Pharmacology & Pharmacy ; Toxicology
关键词[WOS]	NICOTINIC ACETYLCHOLINE-RECEPTORS ; SODIUM-CHANNELS ; GAMMA-CARBOXYGLUTAMATE ; CYSTEINE PATTERN ; VENOM PEPTIDES ; CONANTOKIN-T ; ION-CHANNEL ; ANTAGONIST ; TRYPTOPHAN ; SUBTYPES
收录类别	SCI
语种	英语
WOS记录号	WOS:000227580500012
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1903]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Han, YH,Wang, Q,Jiang, H,et al. Sequence diversity of T-superfamily conotoxins from Conus marmoreus[J]. TOXICON,2005,45(4):481-487.
APA	Han, YH,Wang, Q,Jiang, H,Miao, XW,Chen, JS,&Chi, CW.(2005).Sequence diversity of T-superfamily conotoxins from Conus marmoreus.TOXICON,45(4),481-487.
MLA	Han, YH,et al."Sequence diversity of T-superfamily conotoxins from Conus marmoreus".TOXICON 45.4(2005):481-487.