Suppression of morphine withdrawal syndrome by interleukin-2 and its gene

	Suppression of morphine withdrawal syndrome by interleukin-2 and its gene
	Gu, JF; Yao, MZ; Wang, JH; Zhou, WH; Yang, GD; Liu, HF; Zhang, ZL; Liu, XY
刊名	NEUROREPORT
	2005
卷号	16 期号:4 页码:387-391
关键词	interleukin-2 interleukin-2 gene intrathecal injection morphine withdrawal syndrome
通讯作者	Liu, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,xyliu@sibs.ac.cn
英文摘要	The naloxone-precipitated withdrawal syndrome in mice and rats after intrathecal injection of recombinant human interleukin-2 protein (rIL-2) or its gene was studied. The results showed that rIL-2 could significantly decrease the number of jumps in mice. In rats, rIL-2 significantly suppressed irritating, diarrhea, weight loss, abnormal posture and salivation. Tendencies towards reductions in teeth chewing and dog-shaking were also observed. Furthermore, pcDNA3-IL-2 (8 mu g DNA) had a similar effect as 1 x 10(4) IU rIL-2 protein on inhibition of morphine withdrawal syndrome in mice, and the expression of rIL-2 protein in spinal cord could be detected for 6 days. These findings provided further evidence for the neuroregulatory function of an immunological molecule such as IL-2. (c) 2005 Lippincott Williams T Wilkins.
学科主题	Neurosciences & Neurology
类目[WOS]	Neurosciences
关键词[WOS]	INDUCED IMMUNOSUPPRESSION ; RAT ; RECEPTOR ; EXPRESSION ; BEHAVIOR ; MICE ; IL-2
收录类别	SCI
语种	英语
WOS记录号	WOS:000227964300016
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1902]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Gu, JF,Yao, MZ,Wang, JH,et al. Suppression of morphine withdrawal syndrome by interleukin-2 and its gene[J]. NEUROREPORT,2005,16(4):387-391.
APA	Gu, JF.,Yao, MZ.,Wang, JH.,Zhou, WH.,Yang, GD.,...&Liu, XY.(2005).Suppression of morphine withdrawal syndrome by interleukin-2 and its gene.NEUROREPORT,16(4),387-391.
MLA	Gu, JF,et al."Suppression of morphine withdrawal syndrome by interleukin-2 and its gene".NEUROREPORT 16.4(2005):387-391.