Regulation of the expression of histone H3.3 by differential polyadenylation

	Regulation of the expression of histone H3.3 by differential polyadenylation
	Feng, RR; Tang, XY; Becker, A; Berger, A; Ye, J; Akhmanova, A; Hennig, W
刊名	GENOME
	2005
卷号	48 期号:3 页码:503-510
关键词	histone H3.3 polyadenylation oogenesis spermatogenesis histone translation
通讯作者	Hennig, W (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, DAAD lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,whennig@gmx.de
英文摘要	Previously we have shown that the 3' untranslated regions (UTRs) of the replacement histone genes H3.3.A and H3.3B of Drosophila melanogaster differ in their nucleotide sequences and have different polyadenylation sites. To understand their functional relevance, which might explain the presence and evolutionary conservation of 2 different H3.3 genes, green flourescent protein (GFP) constructs with different 3' UTR sections were studied by the expression of GFP as a marker protein. Here we show that the polyadenylation signals modify the cell-specific translation of the histone replacement variants in testes and ovaries. The H3.3A gene may be required to provide postmeiotic histone H3.3 in the male germ line in transition to chromatin packaging in sperm.
学科主题	Biotechnology & Applied Microbiology; Genetics & Heredity
类目[WOS]	Biotechnology & Applied Microbiology ; Genetics & Heredity
关键词[WOS]	DROSOPHILA-MELANOGASTER ; CHROMOSOMAL-PROTEINS ; CHROMATIN ; GENES ; VARIANTS ; SPECIFY ; SPERM ; HYDEI
收录类别	SCI
语种	英语
WOS记录号	WOS:000230818900014
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1880]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Feng, RR,Tang, XY,Becker, A,et al. Regulation of the expression of histone H3.3 by differential polyadenylation[J]. GENOME,2005,48(3):503-510.
APA	Feng, RR.,Tang, XY.,Becker, A.,Berger, A.,Ye, J.,...&Hennig, W.(2005).Regulation of the expression of histone H3.3 by differential polyadenylation.GENOME,48(3),503-510.
MLA	Feng, RR,et al."Regulation of the expression of histone H3.3 by differential polyadenylation".GENOME 48.3(2005):503-510.