Recent advance on cellular signal transduction in response to virus infections

	Recent advance on cellular signal transduction in response to virus infections
	Yang, K; Wang, C
刊名	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
	2006
卷号	33 期号:12 页码:1138-1145
关键词	PRR PAMP TLR3 RIG-I MDA5 innate immune response
通讯作者	Wang, C (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,cwang01@sibs.ac.cn
英文摘要	How the hosts recognize and clear invading viruses is one of the key issues in molecular immunology. Previous studies uncovered that many early antiviral proteins, such as Type I interferons and PKR, are strongly induced upon virus infection. These proteins not only limit virus replication and spread or cause infected cells to undergo apoptosis, but also induce consequently expression of cytokines and chemokines to initiate acquired immunity. However, the immediate-early signaling events among host and virus interaction were largely unknown. In the past few years, there are great breakthroughs in this rapidly evolving field. TLR3 and RIG-I/MDA5 signaling pathways were shown to play a crucial regulatory role in antiviral processes. These pathways are essential for the vertebrate immune system to recognize and clear RNA virus with different strategies, which are integral parts of innate immune response and directly affect later-stage acquired immunity. The recent know-how on TLR3 and RIG-I/MDA5 signal transduction pathways and their roles in antiviral immunity were summarized.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	TOLL-LIKE RECEPTOR-3 ; DOUBLE-STRANDED-RNA ; NF-KAPPA-B ; INTERFERON REGULATORY FACTOR-3 ; INNATE IMMUNE-RESPONSES ; HEPATITIS-C VIRUS ; INDUCIBLE GENE-I ; RIG-I ; ADAPTER PROTEIN ; ESSENTIAL COMPONENTS
收录类别	SCI
语种	中文
WOS记录号	WOS:000243097200001
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1783]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Yang, K,Wang, C. Recent advance on cellular signal transduction in response to virus infections[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2006,33(12):1138-1145.
APA	Yang, K,&Wang, C.(2006).Recent advance on cellular signal transduction in response to virus infections.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,33(12),1138-1145.
MLA	Yang, K,et al."Recent advance on cellular signal transduction in response to virus infections".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 33.12(2006):1138-1145.