The antitumor activity of TRAIL and IL-24 with replicating oncolytic adenovirus in colorectal cancer

	The antitumor activity of TRAIL and IL-24 with replicating oncolytic adenovirus in colorectal cancer
	Zhao, L; Dong, A; Gu, J; Liu, Z; Zhang, Y; Zhang, W; Wang, Y; He, L; Qian, C; Qian, Q
刊名	CANCER GENE THERAPY
	2006
卷号	13 期号:11 页码:1011-1022
关键词	ZD55 TRAIL Mda-7/IL-24 oncolytic adenovirus cancer gene virotherapy apoptosis
通讯作者	Liu, X (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xyliu@sibs.ac.cn
英文摘要	Melanoma differentiation associated gene-7 (Mda-7)/ IL-24 was previously cloned into ZD55 (an adenovirus with E1B55 deleted) to form ZD55-IL-24, which had much better antitumor effect than Ad-IL-24. According to its good antitumor properties, ZD55-IL-24 has been used in preclinical studies. But ZD55-IL-24 alone still could not completely eradicate established tumors in all nude mice. It was reported that IL-24 could induce and enhance the activity of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) (a member of tumor necrosis factor (TNF) superfamily). Accordingly, the combined use of ZD55-IL-24 and ZD55-TRAIL was carried out in this study. Treatment with both ZD55-IL-24 and ZD55-TRAIL could induce more significant apoptosis in cancer cells in vitro compared with ZD55-IL-24 or ZD55-TRAIL alone. The combination of the two replicative adenoviruses had better antitumor activity in vivo than that of single oncolytic adenovirus and led to complete eradication of xenograft tumors in all treated mice. Upregulation of TRAIL was observed in tumor cells infected with ZD55-IL-24 and studies of the apoptotic cascade regulators indicate that ZD55-IL-24 could further enhance the activation of apoptosis through the TNF family of death receptors. We demonstrated for the first time the potential therapeutic effect of combined ZD55-IL-24 with ZD55-TRAIL for the targeted therapy of cancer.
学科主题	Biotechnology & Applied Microbiology; Oncology; Genetics & Heredity; Research & Experimental Medicine
类目[WOS]	Biotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Medicine, Research & Experimental
关键词[WOS]	DIFFERENTIATION-ASSOCIATED GENE-7 ; CELL LUNG-CANCER ; HUMAN-MELANOMA CELLS ; PROTEIN-KINASE PKR ; TUMOR-SUPPRESSOR ; PROSTATE-CANCER ; UP-REGULATION ; MDA-7 IL24 ; NUDE-MICE ; APOPTOSIS
收录类别	SCI
语种	英语
WOS记录号	WOS:000241158400004
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1772]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhao, L,Dong, A,Gu, J,et al. The antitumor activity of TRAIL and IL-24 with replicating oncolytic adenovirus in colorectal cancer[J]. CANCER GENE THERAPY,2006,13(11):1011-1022.
APA	Zhao, L.,Dong, A.,Gu, J.,Liu, Z.,Zhang, Y.,...&Liu, X.(2006).The antitumor activity of TRAIL and IL-24 with replicating oncolytic adenovirus in colorectal cancer.CANCER GENE THERAPY,13(11),1011-1022.
MLA	Zhao, L,et al."The antitumor activity of TRAIL and IL-24 with replicating oncolytic adenovirus in colorectal cancer".CANCER GENE THERAPY 13.11(2006):1011-1022.