CXC chemokine ligand 13 and CC chemokine ligand 19 cooperatively render resistance to apoptosis in B cell lineage acute and chronic lymphocytic leukemia CD23(+)CD5(+) B cells

	CXC chemokine ligand 13 and CC chemokine ligand 19 cooperatively render resistance to apoptosis in B cell lineage acute and chronic lymphocytic leukemia CD23(+)CD5(+) B cells
	Hu, CS; He, YL; Wang, L; Xiong, J; Zhou, G; Zhang, QP; Gao, QP; Zhang, KJ; Qiao, L; Chang, AE
刊名	JOURNAL OF IMMUNOLOGY
	2006
卷号	177 期号:10 页码:6713-6722
通讯作者	Tan, JQ (reprint author), Anhui Med Univ, Dept Immunol, Sch Basic Med Sci, Hefei 230032, Peoples R China.,jinquan_tan@hotmai.com
英文摘要	CXCL13/CXCR5 and CCL19/CCR7 play a quite important role in normal physiological conditions, but the functions of both chemokine/receptor pairs in pathophysiological events are not well-investigated. We have investigated expression and functions of CXCL13/CXCR5 and CCL19/CCR7 in CD23(+)CD5(+) and CD23(+)CD5(-) B cells from cord blood (CB) and patients with B cell linea-e acute or chronic lymphocytic leukemia (B-ALL or B-CLL). CXCR5 and CCR7 are selectively expressed on B-ALL, B-CLL, and CB CD23(+)CD5(+) B cells at high frequency, but not on CD23+CD5- B cells. Although no significant chemotactic responsiveness was observed, CXCL13 and CCL19 cooperatively induce significant resistance to TNF-alpha-mediated apoptosis in B-ALL and B-CLL CD23(+)CD5(+) B cells, but not in the cells from CB. B-ALL and B-CLL CD23(+)CD5(+) B cells express elevated levels of paternally expressed gene 10 (PEG10). CXCL13 and CCL19 together significantly up-regulate PEG10 expression in the same cells. We have found that CXCL13 and CCL19 together by means of activation of CXCR5 and CCR7 up-regulate PEG10 expression and function, subsequently stabilize caspase-3 and caspase-8 in B-ALL and B-CLL CD23(+)CD5(+) B cells, and further rescue the cells from TNF-a-mediated apoptosis. Therefore, we suggest that normal lymphocytes, especially naive B and T cells, use CXCL13/CXCR5 and CCL19/CCR7 for migration, homing, maturation, and cell homeostasis as well as secondary lymphoid tissues organogenesis. In addition, certain malignant cells take advantages of CXCL13/CXCR5 and CCL19/CCR7 for infiltration, resistance to apoptosis, and inappropriate proliferation.
学科主题	Immunology
类目[WOS]	Immunology
关键词[WOS]	RECEPTOR 9/TECK INTERACTION ; LYMPH-NODES ; DENDRITIC CELLS ; T-LYMPHOCYTES ; MIGRATION ; EXPRESSION ; GENE ; PEG10 ; ACTIVATION ; FOLLICLES
收录类别	SCI
语种	英语
WOS记录号	WOS:000242009700019
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1765]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Hu, CS,He, YL,Wang, L,et al. CXC chemokine ligand 13 and CC chemokine ligand 19 cooperatively render resistance to apoptosis in B cell lineage acute and chronic lymphocytic leukemia CD23(+)CD5(+) B cells[J]. JOURNAL OF IMMUNOLOGY,2006,177(10):6713-6722.
APA	Hu, CS.,He, YL.,Wang, L.,Xiong, J.,Zhou, G.,...&Tan, JQ.(2006).CXC chemokine ligand 13 and CC chemokine ligand 19 cooperatively render resistance to apoptosis in B cell lineage acute and chronic lymphocytic leukemia CD23(+)CD5(+) B cells.JOURNAL OF IMMUNOLOGY,177(10),6713-6722.
MLA	Hu, CS,et al."CXC chemokine ligand 13 and CC chemokine ligand 19 cooperatively render resistance to apoptosis in B cell lineage acute and chronic lymphocytic leukemia CD23(+)CD5(+) B cells".JOURNAL OF IMMUNOLOGY 177.10(2006):6713-6722.