Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models

	Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models
	Xu, LF; Chu, WJ; Qing, XY; Li, S; Wang, XS; Qing, GW; Fei, J; Guo, LH
刊名	NEUROPHARMACOLOGY
	2006
卷号	50 期号:8 页码:934-940
关键词	Dactylicapnos scandens Hutch antidepressant 5-HT (5-hydroxytryptamine noradrenaline (NE) reuptake inhibitor transporter serotonin)
通讯作者	Guo, LH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,guolihe@celstar.com.cn
英文摘要	The protopine isolated from a Chinese herb Dactylicapnos scandens Hutch was identified as an inhibitor of both serotonin transporter and noradrenaline transporter in vitro assays. 5-hydroxy-DL-tryptophan(5-HTP)-induced head twitch response (HTR) and tail suspension test were adopted to study whether protopine has anti-depression effect in mice using reference antidepressant fluoxetine and desipramine as positive controls. In HTR test, protopine at doses of 5, 10, 20 mg/kg dose dependently increase the number of 5-HTP-induced HTR. Protopine at doses of 3.75 mg/kg, 7.5 mg/kg and 30 mg/kg also produces a dose-dependent reduction in immobility in the tail suspension test. The present results open up new possibilities for the use of protopine in the treatment of mood disorders, such as mild and moderate states of depression. (c) 2006 Elsevier Ltd. All rights reserved.
学科主题	Neurosciences & Neurology; Pharmacology & Pharmacy
类目[WOS]	Neurosciences ; Pharmacology & Pharmacy
关键词[WOS]	CNS DRUG DISCOVERY ; NEUROTRANSMITTER TRANSPORTERS ; PHARMACOLOGICAL PROFILE ; MONOAMINE TRANSPORTERS ; AFFECTIVE-DISORDERS ; DEPRESSION ; CLONING ; EPIDEMIOLOGY ; EXPRESSION ; DISEASE
收录类别	SCI
语种	英语
WOS记录号	WOS:000238825000004
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1755]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Xu, LF,Chu, WJ,Qing, XY,et al. Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models[J]. NEUROPHARMACOLOGY,2006,50(8):934-940.
APA	Xu, LF.,Chu, WJ.,Qing, XY.,Li, S.,Wang, XS.,...&Guo, LH.(2006).Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models.NEUROPHARMACOLOGY,50(8),934-940.
MLA	Xu, LF,et al."Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models".NEUROPHARMACOLOGY 50.8(2006):934-940.