A novel M-superfamily conotoxin with a unique motif from Conus vexillum

	A novel M-superfamily conotoxin with a unique motif from Conus vexillum
	Jiang, H; Wang, CZ; Xu, CQ; Fan, CX; Dai, XD; Chen, JS; Chi, CW
刊名	PEPTIDES
	2006
卷号	27 期号:4 页码:682-689
关键词	conotoxin Conus vexillum refolding cDNA cloning electrophysiology
通讯作者	Chi, CW (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,chi@sunm.shcnc.ac.cn
英文摘要	Cone snails are tropical marine mollusks that envenomate prey with a complex mixture of neuropharmacologically active compounds for the purpose of feeding and defence, each evolved to act in a highly specific manner on different parts of the nervous system. Here, we report the peptide purification, molecular cloning, chemical synthesis, and functional characterization of a structurally unique toxin isolated from the venom of Conus vexillum. The novel peptide, designated Vx2, was composed of 21 amino acid residues cross-linked by 3 disulfide bonds (WIDPSHYCCCGGGCTDDCVNC). Intriguingly, its mature peptide sequence shows low level of similarity with other identified conotoxins, and its unique motif (-CCCGGGC-) was not reported in other Conus peptides. However, its signal peptide sequence shares high similarity with those of the M-superfamily conotoxins. Hence, Vx2 could be classified into a new family of the M-superfamily. (c) 2005 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology; Pharmacology & Pharmacy
类目[WOS]	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]	BUTHUS-MARTENSI KARSCH ; NICOTINIC ACETYLCHOLINE-RECEPTOR ; SODIUM-CHANNELS ; OMEGA-CONOTOXIN ; PEPTIDE ; PRECURSOR ; VENOMS ; THERAPEUTICS ; CONOPEPTIDES ; GENERATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000237047000011
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1709]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Jiang, H,Wang, CZ,Xu, CQ,et al. A novel M-superfamily conotoxin with a unique motif from Conus vexillum[J]. PEPTIDES,2006,27(4):682-689.
APA	Jiang, H.,Wang, CZ.,Xu, CQ.,Fan, CX.,Dai, XD.,...&Chi, CW.(2006).A novel M-superfamily conotoxin with a unique motif from Conus vexillum.PEPTIDES,27(4),682-689.
MLA	Jiang, H,et al."A novel M-superfamily conotoxin with a unique motif from Conus vexillum".PEPTIDES 27.4(2006):682-689.