Dopamine promotes the survival of embryonic striatal cells: Involvement of superoxide and endogenous NADPH oxidase

	Dopamine promotes the survival of embryonic striatal cells: Involvement of superoxide and endogenous NADPH oxidase
	Ma, LP; Zhou, JW
刊名	NEUROCHEMICAL RESEARCH
	2006
卷号	31 期号:4 页码:463-471
关键词	embryonic dopamine striatum neural precursor cells NADPH oxidase antioxidant activity
通讯作者	Zhou, JW (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Bldg 23,Room 316,320 Yueyang Rd, Shanghai 200031, Peoples R China.,jwzhou@sibs.ac.cn
英文摘要	The dopaminergic system appears early in mammalian brain development, and a neurodevelopmental role for dopamine (DA) has been suggested. In the present study, we found that DA markedly promoted the survival of embryonic striatal cells in cultures. The failure of DA receptor antagonists to block this survival-promoting effect and the capability of S-apomorphine, which is devoid of DA receptor agonist activity but possesses antioxidative activity as R-apomorphine and DA, to completely mimic this effect suggested that DA receptor activation was not required in the survival-promoting effect elicited by DA, and its antioxidative activity might be involved. Moreover, it was found that mRNA of NADPH oxidase was expressed in the embryonic striatum. Furthermore, DPI or apocynin, NADPH oxidase inhibitors, promoted the survival of embryonic striatal cells. Addition of either DA or DPI into striatal cell cultures decreased the superoxide level. These results indicate that the mechanisms underlying the neuroprotective effects of DA were likely associated with its antioxidative activity. NADPH oxidase might contribute, at least in part, to ROS generation.
学科主题	Biochemistry & Molecular Biology; Neurosciences & Neurology
类目[WOS]	Biochemistry & Molecular Biology ; Neurosciences
关键词[WOS]	NEUROTROPHIC FACTOR ; RAT-BRAIN ; SUBSTANTIA-NIGRA ; MESSENGER-RNA ; IN-VITRO ; NEURONS ; CULTURES ; DEATH ; NEUROTRANSMITTERS ; DIFFERENTIATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000238138800003
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1708]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Ma, LP,Zhou, JW. Dopamine promotes the survival of embryonic striatal cells: Involvement of superoxide and endogenous NADPH oxidase[J]. NEUROCHEMICAL RESEARCH,2006,31(4):463-471.
APA	Ma, LP,&Zhou, JW.(2006).Dopamine promotes the survival of embryonic striatal cells: Involvement of superoxide and endogenous NADPH oxidase.NEUROCHEMICAL RESEARCH,31(4),463-471.
MLA	Ma, LP,et al."Dopamine promotes the survival of embryonic striatal cells: Involvement of superoxide and endogenous NADPH oxidase".NEUROCHEMICAL RESEARCH 31.4(2006):463-471.