A novel spermatogenesis-specific uPAR gene expressed in human and mouse testis

	A novel spermatogenesis-specific uPAR gene expressed in human and mouse testis
	Teng, XK; Yang, J; Xie, Y; Ni, ZM; Hu, RY; Shi, L; Lin, ZX; Hu, LD; Zhao, GP; Ding, XY
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2006
卷号	342 期号:4 页码:1223-1227
关键词	urokinase receptor spermatogenesis testis scleroderma peripheral leukocytes
通讯作者	Ding, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200233, Peoples R China.,xyding@sunm.shcnc.ac.cn ; xykoiig@srcb.ac.cn
英文摘要	The urokinase receptor, uPAR, which binds to the Urinary-type plasminogen activator, controls matrix degradation in the processes of tissue remodeling, cell migration, and invasion. In the present study, we found a new urokinase receptor gene that encodes a 249-amino acid putative protein. Northern blot analysis showed specific expression in the testis of this gene, which we named the spermatogenesis-related gene (SGRG). In situ hybridization revealed a strong expression signal for SGRG in spermatogonia, but not in spermatocytes. Therefore, we conjecture that SGRG may regulate spermatocyte migration through breakdown of extracellular matrix protein barriers in spermatogenesis. Since SGRG is specifically expressed in spermatogonia, it provides an attractive candidate for development of it contraceptive vaccine. (c) 2006 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	UROKINASE PLASMINOGEN-ACTIVATOR ; SERTOLI CELLS ; RECEPTOR ; LOCALIZATION ; SURFACE ; ADHESION ; CLONING ; TRACT
收录类别	SCI
语种	英语
WOS记录号	WOS:000236316100032
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1701]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Teng, XK,Yang, J,Xie, Y,et al. A novel spermatogenesis-specific uPAR gene expressed in human and mouse testis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,342(4):1223-1227.
APA	Teng, XK.,Yang, J.,Xie, Y.,Ni, ZM.,Hu, RY.,...&Kong, XY.(2006).A novel spermatogenesis-specific uPAR gene expressed in human and mouse testis.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,342(4),1223-1227.
MLA	Teng, XK,et al."A novel spermatogenesis-specific uPAR gene expressed in human and mouse testis".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 342.4(2006):1223-1227.