Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling

	Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling
	Wang, YY; Tang, YW; Teng, L; Wu, YL; Zhao, XH; Pei, G
刊名	NATURE IMMUNOLOGY
	2006
卷号	7 期号:2 页码:139-147
通讯作者	Pei, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Lab Mol Cell Biol, Shanghai 200031, Peoples R China.,gpei@sibs.ac.cn
英文摘要	Tumor necrosis factor receptor-associated factor 6 (TRAF6) is critical for mediating Toll-like receptor (TLR)-interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappa B and AP-1, transcriptional activators of innate immunity. Here we show that beta-arrestins, a family of multifunctional proteins, directly interacted with TRAF6 after TLR-IL-1R activation. Formation of the beta-arrestin- TRAF6 complex prevented autoubiquitination of TRAF6 and activation of NF-kappa B and AP-1. Endotoxin-treated beta-arrestin 2-deficient mice had higher expression of proinflammatory cytokines and were more susceptible to endotoxic shock. Thus, beta-arrestins are essential negative regulators of innate immune activation via TLR-IL-1R signaling.
学科主题	Immunology
类目[WOS]	Immunology
关键词[WOS]	NF-KAPPA-B ; TRANSCRIPTION FACTORS ; BETA-ARRESTIN-2 ; ACTIVATION ; KINASE ; ENZYME ; UBIQUITINATION ; INTERLEUKIN-1 ; TRANSDUCTION ; RESPONSES
收录类别	SCI
语种	英语
WOS记录号	WOS:000234801700014
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1674]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Wang, YY,Tang, YW,Teng, L,et al. Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling[J]. NATURE IMMUNOLOGY,2006,7(2):139-147.
APA	Wang, YY,Tang, YW,Teng, L,Wu, YL,Zhao, XH,&Pei, G.(2006).Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling.NATURE IMMUNOLOGY,7(2),139-147.
MLA	Wang, YY,et al."Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling".NATURE IMMUNOLOGY 7.2(2006):139-147.