Targeting strategies for adeno-associated viral vector

	Targeting strategies for adeno-associated viral vector
	Wang, YG; Huang, F; Cai, R; Qian, C; Liu, XY
刊名	CHINESE SCIENCE BULLETIN
	2007
卷号	52 期号:12 页码:1590-1599
关键词	AAV targeting gene therapy
通讯作者	Qian, C (reprint author), Zhejiang Sci Tech Univ, Coll Life Sci, Xinyuan Inst Med & Biotechnol, Hangzhou 310018, Peoples R China.,cqian3184@yahoo.com.cn ; xyliu@sibs.ac.cn
英文摘要	Adeno-associated virus (AAV) has rapidly become a promising gene delivery vector for its excellent advantages of low pathogenicity and long-term gene expression over other viral vectors for human gene therapy. However, the disadvantage of AAV for clinical gene therapy is the broad host range and the lack of tissue or cell specificity, which makes AAVs relatively inefficient gene delivery to target cells and short of safety. Therefore, it is required to improve the targeting capability of recombinant adeno-associated virus (rAAV) for successful gene therapy. At present, the successful identification of various-serotype AAVs and the improvement of rAAV production technology make it feasible to explore new applications of rAAV vector in clinical gene therapy trials. Moreover, the current development in targeting strategy has brought a bright prospect to rAAV vectors. Many studies have demonstrated that targeting gene therapy based on rAAV vectors could be achieved through transcription targeted, conjugate targeted, receptor targeted, gene recombinant targeted strategies, etc. This report gives a comprehensive review of the recent developments of targeting strategies for rAAV vectors.
学科主题	Science & Technology - Other Topics
类目[WOS]	Multidisciplinary Sciences
关键词[WOS]	MEDIATED GENE-TRANSFER ; CENTRAL-NERVOUS-SYSTEM ; VIRUS VECTORS ; TRANSGENE EXPRESSION ; IN-VIVO ; HEMOPHILIA-B ; SUSTAINED CORRECTION ; TELOMERASE ACTIVITY ; THERAPY VECTORS ; SKELETAL-MUSCLE
收录类别	SCI
语种	英语
WOS记录号	WOS:000247578400002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1622]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Wang, YG,Huang, F,Cai, R,et al. Targeting strategies for adeno-associated viral vector[J]. CHINESE SCIENCE BULLETIN,2007,52(12):1590-1599.
APA	Wang, YG,Huang, F,Cai, R,Qian, C,&Liu, XY.(2007).Targeting strategies for adeno-associated viral vector.CHINESE SCIENCE BULLETIN,52(12),1590-1599.
MLA	Wang, YG,et al."Targeting strategies for adeno-associated viral vector".CHINESE SCIENCE BULLETIN 52.12(2007):1590-1599.