ADAM23 plays multiple roles in neuronal differentiation of P19 embryonal carcinoma cells

	ADAM23 plays multiple roles in neuronal differentiation of P19 embryonal carcinoma cells
	Sun, YP; Wang, YM; Zhang, J; Tao, J; Wang, C; Jing, NH; Wu, CQ; Deng, KJ; Qiao, SY
刊名	NEUROCHEMICAL RESEARCH
	2007
卷号	32 期号:7 页码:1217-1223
关键词	ADAM23 P19 embryonal carcinoma neural differentiation
通讯作者	Qiao, SY (reprint author), Fudan Univ, Sch Life Sci, Inst Genet, State Key Lab Genet Engn, 220 Han Dan Rd, Shanghai 200433, Peoples R China.,syqiao@fudan.edu.cn
英文摘要	ADAM23, belonging to ADAM (A Disintegrin And Metalloprotease) protein family, is mainly expressed in brain. P19 cells could differentiate into neuroectodermal cell lineage after cell aggregates have been induced by retinoic acid (RA). In this report, we show that the post-transcriptional and post-translational processes of ADAM23 are regulated during the differentiation of P19 cells. In P19-derived neurons, ADAM23 is polarized distributed in the proximal part. To explore the possible roles of ADAM23 during P19 cell neuronal differentiation, ADAM23-RNAi P19 cell lines were established. These transfected cells could differentiate into neurofilament-expression neurons in the absence of RA, whereas wild-type P19 cell can not. These results suggest ADAM23 may play roles in both early and later stage of neuronal differentiation.
学科主题	Biochemistry & Molecular Biology; Neurosciences & Neurology
类目[WOS]	Biochemistry & Molecular Biology ; Neurosciences
关键词[WOS]	METALLOPROTEASE-DISINTEGRIN ; NEURAL DIFFERENTIATION ; RETINOIC ACID ; PROTEINS ; EXPRESSION ; AGGREGATION ; DROSOPHILA ; INTEGRIN ; FAMILY ; BRAIN
收录类别	SCI
语种	英语
WOS记录号	WOS:000246768100014
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1583]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Sun, YP,Wang, YM,Zhang, J,et al. ADAM23 plays multiple roles in neuronal differentiation of P19 embryonal carcinoma cells[J]. NEUROCHEMICAL RESEARCH,2007,32(7):1217-1223.
APA	Sun, YP.,Wang, YM.,Zhang, J.,Tao, J.,Wang, C.,...&Qiao, SY.(2007).ADAM23 plays multiple roles in neuronal differentiation of P19 embryonal carcinoma cells.NEUROCHEMICAL RESEARCH,32(7),1217-1223.
MLA	Sun, YP,et al."ADAM23 plays multiple roles in neuronal differentiation of P19 embryonal carcinoma cells".NEUROCHEMICAL RESEARCH 32.7(2007):1217-1223.