Neurodegeneration-related aminoacy-tRNA synthetases

	Neurodegeneration-related aminoacy-tRNA synthetases
	Zhu, B; Wang, ED
刊名	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
	2007
卷号	34 期号:6 页码:562-566
关键词	aminoacyl-tRNA synthetase tyrosyl-tRNA synthetase glycyl-tRNA synthetase alanyl-tRNA synthetase neurodegeneration Charcot-Marie-Tooth disease Purkinje cell
通讯作者	Wang, ED (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,edwang@sibs.ac.cn
英文摘要	Aminoacyl-tRNA synthetases (AARSs) catalyze aminoacylation of their tRNAs for protein biosynthesis. As belong to one of the most ancient and conserved enzyme family their additional functions in mammalian cells were focused recently. Mutations in tyrosyl-tRNA synthetase, glycyl-tRNA synthetase and alanyl-tRNA synthetase from patients and mice models were identified to cause two subtypes of Charcot-Marie-Tooth disease and cerebellar Purkinje cell loss, respectively. These mutations affect different functions of the three enzymes including aminoacylation, editing and unknown functions. These results combined AARSs with neurodegeneration and gave new sights into neuropathy.
学科主题	Biochemistry & Molecular Biology; Biophysics
类目[WOS]	Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]	PROTEIN-SYNTHESIS ; ANGIOGENESIS ; MUTATIONS ; NEUROPATHY ; CYTOKINE ; FRAGMENT ; GROWTH ; 2D
收录类别	SCI
语种	中文
WOS记录号	WOS:000247615100002
内容类型	期刊论文
版本	出版稿
源URL	[http://202.127.25.143/handle/331003/1580]
专题	上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式 GB/T 7714	Zhu, B,Wang, ED. Neurodegeneration-related aminoacy-tRNA synthetases[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2007,34(6):562-566.
APA	Zhu, B,&Wang, ED.(2007).Neurodegeneration-related aminoacy-tRNA synthetases.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,34(6),562-566.
MLA	Zhu, B,et al."Neurodegeneration-related aminoacy-tRNA synthetases".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 34.6(2007):562-566.